Parenteral nutrition admixtures for pediatric patients compounded with highly refined fish oil-based emulsion. Assessment of physicochemical stability英文资料.PDFVIP

Clinical Nutrition xxx (2014) 1e5 Contents lists available at ScienceDirect Clinical Nutrition journal homepage: http://www. /locate/clnu Original article Parenteral nutrition admixtures for pediatric patients compounded with highly refined fish oil-based emulsion: Assessment of physicochemical stability M.L. Forchielli a, *, A. Bonoli c, I. Preite c, A. Stancari b, S. Maselli b, A.M. Guarguaglini b, I. Mignini b a,1 b b,1 , M. Masi , C. Puggioli , G. Bersani a Paediatrics, S. Orsola-Malpighi Medical School, Bologna, Italy b Pharmacy Service, S. Orsola-Malpighi Hospital, Medical School, Bologna, Italy c Civil, Environmental and Materials Engineering Department, University of Bologna, Italy a r t i c l e i n f o s u m m a r y Article history: Fish oil-based emulsion is increasingly used in pediatric patients receiving Parenteral Nutrition (PN). Received 28 May 2013 However, its unique use in children on long-term PN is nutritionally debatable as some patients are Accepted 27 December 2013 better off with a mixture of long-chain (LCT) or long-chain þ medium-chain (LCT þ MCT) triglycerides along with Fish Oil (FO). Keywords: Lipid emulsions are safely infused when particle diameter ranges between 0.4 and 1.0 micron (like Omega-3 fatty acids chylomicra), according to European guidelines. No data exis