雌激素受体在脑内的表达与缺血再灌注损伤.pdfVIP

生 物 技 术 通 讯 LETTERSINBIOTECHNOLOGY Vol.26No.4 Jul.,2015 583 doi: 10.3969/j.issn.1009-0002.2015.04.030 综 述 雌激素受体在脑内的表达与缺血再灌注损伤 1,2 3 1 1 张志春 ，邹萍 ，黄亮 ，邹伟 1. 辽宁师范大学 生命科学学院，辽宁 大连 116029；2. 解放军215医院，辽宁 大连 116041； 3. 大连大学 师范学院，辽宁 大连 116622 ［摘要］ 雌激素作为一种内源性激素参与多器官生理过程的调节，通过与雌激素受体结合或介导不同雌激素受体间 的协作而发挥效应，其中在中枢神经系统疾病的发展中具有保护作用已受到人们的广泛关注。脑卒中作为一种高发 疾病，具有明显的性别差异性，因此对脑内雌激素的研究为脑卒中的预防及治疗提供了新的方向。我们针对雌激素 受体不同亚型在脑内的分布及其在缺血再灌注损伤中的作用研究进展做简要综述。 ［关键词］ 雌激素；雌激素受体；脑卒中；缺血再灌注 ［中图分类号］ Q25 ［文献标识码］ A ［文章编号］ 1009-0002（2015）04-0583-04 Expression of Estrogen Receptor in Brain and Ischemia-Reperfusion Injury 1,2 3 1 1 ZHANG Zhi-Chun , ZOU Ping, HUANG Liang, ZOU Wei * 1. College of Life Science, Liaoning Normal University, Dalian 116029; 2. The 215th Hospital of PLA, Dalian 116041; 3. Normal College, University of Dalian, Dalian 116622; China *Corresponding author, E-mail: weizou60@ ［Abstract］ The estrogen is a kind of human endogenous hormone which plays an important role in regulating the physiological processes of multiple organ, plays a role through conjunction with their receptors or mediated col⁃ laboration between different estrogen receptors. To plays a protective role in the development of the central ner⁃ vous system diseases has been paid attention by people. As a high incidence of disease, stroke has obvious gen⁃ der differences. The study of estrogen in the brain for the prevention and treatment of cerebral apoplexy provides a new research direction. In this paper, the distribution of estrogen receptor in different subtypes in the brain and its role in ischemia-reperfusion injury research progress were reviewed. ［Key words］ estrogen; estrogen