Neuroinlfammation+and+comorbidities+are+frequently+ignored+factors+in+CNS+pathology.pdf

NEURAL REGENERATION RESEARCH September 2015,Volume 10,Issue 9 INVITED REVIEW Neuroinflammation and comorbidities are frequently ignored factors in CNS pathology 2 1, 2 1, 3 4 1, 2, * Raluca Elena Sandu , Ana Maria Buga , Adriana Uzoni , Eugen Bogdan Petcu , Aurel Popa-Wagner 1 Department of Psychiatry, University of Medicine Rostock, Germany 2 Center of Clinical and Experimental Research, University of Medicine and Pharmacy Craiova, Romania 3 Biochemistry Department, University of Medicine and Pharmacy “Victor Babes” Timisoara, Romania 4 Griffith University School of Medicine, Regenerative Medicine Centre, Brisbane, Australia Abstract *Correspondence to: Virtually all drug interventions that have been successful pre-clinically in experimental stroke have Aurel Popa-Wagner, M.D., Ph.D., failed to prove their efficacy in a clinical setting. This could be partly explained by the complexity aurel.popa-wagner@med.uni-rostock.de. and heterogeneity of human diseases as well as the associated co-morbidities which may render neuroprotective drugs less efficacious in clinical practice. One aspect of crucial importance in the doi: 10.4103/1673-5374.165208 physiopathology of stroke which is not completely understood is neuroinflammation. At the pres- / ent time, it is becoming evident that subtle, but continuous neuroinflammation can provide the ground for disorders such as cerebral small vessel disease. Moreover, advanced aging and a number Accepted: 2015-07-09 of highly prevalent risk factors such as obesity, hypertension,