Repair+of+peripheral+nerve+defects+with+chemically+extracted+acellular+nerve+allografts+loaded+with+neurotrophic+factors-transfected+bone+marrow+mesenchymal+stem+cells.pdfVIP

NEURAL REGENERATION RESEARCH September 2015,Volume 10,Issue 9 RESEARCH ARTICLE Repair of peripheral nerve defects with chemically extracted acellular nerve allografts loaded with neurotrophic factors-transfected bone marrow mesenchymal stem cells 1, 2, * 1 3 3 4 5 2, * Yan-ru Zhang , Ka Ka , Ge-chen Zhang , Hui Zhang , Yan Shang , Guo-qiang Zhao , Wen-hua Huang 1 Medical College, Henan Polytechnic University, Jiaozuo, Henan Province, China 2 Institute of Clinical Anatomy, Southern Medical University, Guangzhou, Guangdong Province, China 3 Department of Orthopedics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China 4 Department of Laboratory Medicine, Children’s Hospital of Zhengzhou, Zhengzhou, Henan Province, China 5 School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan Province, China Abstract *Correspondence to: Chemically extracted acellular nerve allografts loaded with brain-derived neurotrophic fac- Wen-hua Huang, Ph.D. or Yan-ru Zhang, tor-transfected or ciliary neurotrophic factor-transfected bone marrow mesenchymal stem jiaoxueban2010@126.com. cells have been shown to repair sciatic nerve injury better than chemically extracted acellular nerve allografts alone, or chemically extracted acellular nerve allografts loaded with bone orcid: marrow mesenchymal stem cells. We hypothesized that these allografts compounded with both 0000-0001-6965-5898 (Wen-hua Huang) brain-derived neurotrophic factor- and ciliary neurotrophic