Prospective Randomized Trial on Radiation Dose Estimates of CT Angiography Applying Iterative Image Reconstruction The PROTECTION V Study》.pdf

J A C C : C A R D I O V A S C U L A R I M A G I N G V O L . 8 , N O . 8 , 2 0 1 5 ª 2 0 1 5 B Y T H E A M E R I C A N C O L L E G E O F C A R D I O L O G Y F O U N D A T I O N I S S N 1 9 3 6 - 8 7 8 X / $ 3 6 . 0 0 P U B L I S H E D B Y E L S E V I E R I N C . h t t p : / / d x . d o i . o r g / 1 0 . 1 0 1 6 / j . j c m g . 2 0 1 5 . 0 2 . 0 2 4 Prospective Randomized Trial on Radiation Dose Estimates of CT Angiography Applying Iterative Image Reconstruction The PROTECTION V Study Simon Deseive, MD,*y Marcus Y. Chen, MD,z Grigorios Korosoglou, MD,x Jonathon Leipsic, MD, k Eugenio Martuscelli, MD,{ Patricia Carrascosa, MD,# Saeed Mirsadraee, MD,** Charles White, MD,yy Martin Hadamitzky, MD,y Stefan Martinoff, MD,y Anna-Leonie Menges,*y Bernhard Bischoff, MD,zz Steffen Massberg, MD,*y Jörg Hausleiter, MD*y ABSTRACT OBJECTIVES The purpose of this study was to assess the potential of iterative image reconstruction (IR) of images for radiation dose reduction in coronary computed tomography angiography (CTA). Therefore, IR in combination with 30% tube current reduction was compared with standard scanning with filtered back projection (FBP) reconstruction. BACKGROUND Lately, new IR techniques with advanced raw data processing have been introduced by different computed tomography vendors, thus allowing for either image noise reduction at unchanged radiation dose levels or radiation dose reductions at comparable image noise levels. METHODS In this prospective, multicenter, multivendor noninferiority trial, we randomized 400 consecutive patients to 1 of 2 groups: a control group using standard FBP image reconstruction and standard tube current or an interventional group using IR technique and 30% tube current