微囊藻毒素对小鼠的免疫毒性的研究.pdfVIP

6．微囊藻毒素能降低SRBC免疫小鼠的抗体反应，提示微囊藻毒素能抑制机体的 体液免疫功能。 7．微囊藻毒素经腹腔注射染毒小鼠14天后，高剂量组小鼠T淋巴细胞增殖、转化 能力明显降低po．01)，表明微囊藻毒素可能抑制机体的细胞免疫功能。 关键词：微囊藻细胞抽提物，微囊藻毒索，小鼠，免疫毒性 H Abstract area of offreshwater Microcystins potent species cyanohacteria, family hepatotoxiusproducedby toxins hasalso primarilyMicrocysas are been aeru丽Bosa．Toxicologically,theseprimarilyhepatotoxic．It that age tumor inanimals．In studieshave reported microcystinspotent promoters humans,epidemiological somem∞sof China．Inthe aimedtoevaluatethetoxic ofthein]111unc to preaentstudy,we responses systemMicrocystis cellextlacts micein to in order evidencefor containingmicrocystin-LRKnnming provide illuminating Theresultsofisolationandcultureof froma inHenan obtained reservoir Microcystis province revealedthat could wellinMA from were Microcystisaeruginosagrow medium．MicrocystiusMicrocystis isolated tothe ofLeiet cellextractsshowedthatthe method a1．HPLC of according analysisMicrocystis main was andallotherkindsof werebelowthelimitsofdetection． componentmicrocystin-LR microcystins totalconcentrationofthetoxinwas110．4 cellextracts． Therefore，the mi