《Osteopontin is a promoter for hepatocellular carcinoma metastasis： a summary of 10 years of studies.》.pdf

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《Osteopontin is a promoter for hepatocellular carcinoma metastasis： a summary of 10 years of studies.》.pdf

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Front．Med．2014，8(1)：24—32 DOIlO．1007／s11684—014—03l2—8 REⅥEW Osteopontinisapromoterforhepat0Ce¨UIarcarcinoma metastasis：asummaryof10yearsofstudies LunxiuQin Department Surgery,HuashanHospital,FudanUniversity,Shanghai200040,China ◎ HigherEducationPressandSpringer-VerlagBerlinHeidelberg2014 Abstract Inthisreview,wesummarizethenovelfindingsfrom ourseriesofstudiesontheleadingmetastasis． relatedgene．osteopontin(OPN)．Inourpreviousgeneexpressionprofilingstudy,0PNwasjdentifiedasoneofthe leadinggenesassociatedwiththemetastasisofhepat0cellularcarcinoma(HCC)．Weofcusedon0PN toevaluate itsprognosticvaluesandimportantrolesinHCC metastasis．A retrospectivestudyoflargecohortsofHCC patientsdemonstrated thatplasma0PN levelwasoneoftheleadingindependentprognosticfactorsforHCC patients，evenintheearlystageofHCC，andcouldserveasasurrogateserologicbiomarkerofrmonitoringthe treatmentresponseandtumorrecurrenceafterHCC resection．Usingboth ／nvitroandinvivoinvestigations．we ofund that0PN hasanimportantroleinmetastasisandtumorgrowth ofHCC andisanaRractivepotential therapeutictargetofrcombating HCC metastasis．W ealso ofund that0PN HCC cellshavemuch more amplificationsatchromosomalregions．andpromoterpolymorphismsareimportantintheregulationof0PN expressionandtumorgrowthandIungmetastasisofHCC． Keywords osteopontin(OPN)；hepatocellularcarcinoma；metastasis；prognosis；therapeutictraget；biomarker；genetic polymorphism IntroductiOn metastasisofhepatocellularcracinoma (HCC) 1『41．we ofcused on OPN to evaluate its prognostic values and Osteopontinf0PN orSPP11isasecretednon．collagenous， importantrolesinHCC metastasis．A retrospectivesutdyof sialicacid．rich，chemokine．1ikeextracellularmatrix(ECM1 largecohortsofHCCpatientsdemonsrtatedthatplasma0PN protein．OPN isaglycosylatedphosphOproteinthatactsasa levelwasoneof