《Potassium dihydrogen phosphate catalyzed one-pot synthesis of 2,4,5-triaryl-1H-imidazoles》.pdfVIP

Available online at Chinese Chemical Letters 21 (2010) 429–432 /locate/cclet Potassium dihydrogen phosphate catalyzed one-pot synthesis of 2,4,5-triaryl-1H-imidazoles Ratnadeep S. Joshi, Priyanka G. Mandhane, Mohammad U. Shaikh, CRajesh P. Kale, Charansingh H. Gill * H_NE5E Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra 431 004, India Received 26 August 2009 Abstract A simple and efficient method has been developed; benzil/benzoin undergoes smooth condensation with various substituted aldehyde and ammonium acetate in the presence of potassium dihydrogen phosphate (KH PO ) under mild reaction conditions to 2 4 afford the corresponding trisubstituted imidazole in excellent yields. The method for synthesis of product, the reaction mixture was reflux in ethanol for 40–90 min. The present method is simple, efficient, and cost-effective. # 2009 Charansingh H. Gill. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. Keywords: Potassium dihydrogen phosphate (KH PO ); 2,4,5-Triaryl-1H–imidazole; Benzil; Benzoin; Aldehyde; Ammonium acetate 2 4 Recently interest in imidazole-containing structures stems from their widespread occurrence in molecules have been 口HEM_CAL exhibits significant activity and their use in synthetic chemistry. Substituted imidazoles a