吡咯并菲啶酮构建方法学研究进展有机化学.pdfVIP

DOI: 10.6023/cjoc201404041 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 吡咯并菲啶酮构建方法学研究进展 丛 蔚a,b 徐进宜*,a,b 姚和权*,a,b (a 中国药科大学天然药物活性组分与药效国家重点实验室 南京 210009) (b 中国药科大学药学院 南京 210009) 摘要 吡咯并菲啶酮母核广泛存在于石蒜科生物碱中, 该系列的生物碱展示出很多有价值的生物活性. 吡咯并菲啶酮 独特的结构吸引了众多学者对其合成进行探索研究. 在过去的几十年中, 很多有价值的构建方法被报道, 其中主要以 过渡金属催化或自由基历程等分子内或分子间偶联反应为主. 对其构建方法学进行了系统地综述. 关键词 吡咯并菲啶酮; 方法学; 偶联反应; 金属催化; 自由基反应 Recent Advances on Construction of Pyrrolophenanthridone Skeleton Cong, Weia,b Xu, Jinyi*,a,b Yao, Hequan*,a,b a ( State Key Laboratory of Natural Medicines (SKLNM), China Pharmaceutical University, Nanjing 210009) b ( Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009) Abstract Pyrrolophenanthridone is a common structural motif existing in a number of amaryllidaceae alkaloids, many of which possess a wide range of biological activities. The intriguing structural feature and significant biological activity have attracted much attention from synthetic communities. In the past decades, several excellent synthetic methodologies have been reported, in which intramolecular or intermolecular cross-coupling reaction through transition-metal catalyzed or radical pathway represents the most straightforward method for construction of this skeleton. This review focuses on the construction