Human T Cell and Antibody-Mediated Responses to the Mycobacterium tuberculosis Recombinant 85A, 85B, and ESAT-6 Antigens.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2011, Article ID 351573, 10 pages doi:10.1155/2011/351573 Research Article Human T Cell and Antibody-Mediated Responses to the Mycobacterium tuberculosis Recombinant 85A, 85B, and ESAT-6 Antigens Gilson C. Macedo,1, 2 Adriana Bozzi,1 Helena Rachel Weinreich,3 Andre Bafica,4 Henrique C. Teixeira,2 and Sergio C. Oliveira1 1 Laboratory of Immunology of Infectious Diseases, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil 2 Department of Parasitology, Microbiology and Immunology, Biological Sciences Institute, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil 3 Oswaldo Cruz Health Center, Belo Horizonte-Minas Gerais, 30180-080 Belo Horizonte, MG, Brazil 4 Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, 88040-900 Florianopolis, MG, Brazil Correspondence should be addressed to Sergio C. Oliveira, scozeus@icb.ufmg.br Received 14 September 2010; Revised 1 November 2010; Accepted 5 November 2010 Academic Editor: James Triccas Copyright © 2011 Gilson C. Macedo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Tuberculosis remains a major health problem throughout the world causing large number of deaths. Effective disease control and eradication programs require the identification of major antigens recognized by the protective responses against M. tuberculosis. In this study, we have investigated humoral and cellular immune responses to M. tuberc