Hydrogen Peroxide in Inflammation Messenger, Guide, and Assassin.pdfVIP

Hindawi Publishing Corporation Advances in Hematology Volume 2012, Article ID 541471, 6 pages doi:10.1155/2012/541471 Review Article Hydrogen Peroxide in Inflammation: Messenger, Guide, and Assassin C. Wittmann,1 P. Chockley,1 S. K. Singh,1 L. Pase,2 G. J. Lieschke,3 and C. Grabher1 1 Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT), 76133 Karlsruhe, Germany 2 Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia 3 Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia Correspondence should be addressed to C. Grabher, clemens.grabher@ Received 9 February 2012; Accepted 29 April 2012 Academic Editor: Christopher Hall Copyright © 2012 C. Wittmann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Starting as a model for developmental genetics, embryology, and organogenesis, the zebrafish has become increasingly popular as a model organism for numerous areas of biology and biomedicine over the last decades. Within haematology, this includes studies on blood cell development and function and the intricate regulatory mechanisms within vertebrate immunity. Here, we review recent studies on the immediate mechanisms mounting an inflammatory response by in vivo analyses using the zebrafish. These recently revealed novel roles of the reactive oxygen species hydrogen peroxide that have changed our view on the initiation of a granulocytic inflammatory response. 1. Introduction damage that may become fatal. Failure to resolve an immune