环丙沙星在大鼠体内的生理药动学模型的血流图设计.pdfVIP

中国农业科学 2010,43(18):3857-3861 Scientia Agricultura Sinica doi: 10.3864/j.issn.0578-1752.2010.18.021 环丙沙星在大鼠体内的生理药动学模型的血流图设计 1 2 1 1 罗显阳 ，蔡芳芹 ，远立国 ，刘雅红 1 2 （华南农业大学兽医学院，广州 510642 ； 福建省动物卫生监督所，福州 350003 ） 摘要：【目的】建立更能准确预测环丙沙星在大鼠体内药物浓度经时变化的生理药动学模型。【方法】通过搜 集环丙沙星的理化性质、药动学特点及大鼠的生理生化参数，根据生理学和解剖学知识及质能守恒定律，对模型 进行了必要的前提假设。【结果】成功设计了环丙沙星在大鼠的生理药动学模型的血流图。【结论】血流图的成功 设计，为环丙沙星在大鼠的生理药动学模型的建立奠定了良好的基础。 关键词：环丙沙星；生理药动学模型；血流图 Rheogram of Physiologically Based Pharmacokinetic Model of Ciprofloxacin in Rats in vivo 1 2 1 1 LUO Xian-yang , CAI Fang-qin , YUAN Li-guo , LIU Ya-hong 1 2 ( College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642; Institute of Fujian Animal Health Inspection, Fuzhou 350003) Abstract: 【Objective 】 The objective of the study is to develop a physiologically based pharmacokinetic model for ciprofloxacin in rats to predict drug concentration changed with time more accurately. 【Method 】 Through collecting the physico chemical properties and pharmacokinetic characteristics of ciprofloxacin, and the physiological and physiochemical parameters of rats, a model was hypothesized according to physiology and anatomy and mass-energy conservation laws. 【Result 】 Rheogram of physiologically based pharmacokinetic model of ciprofloxacin in rats was designed successfully. 【Conclusion 】 The successful design of rheogram has laid a good foundation for establishment of the