a retrospective analysis of ten symptomatic multiple myeloma patients with hiv infection a potential therapeutic effect of haart in multiple myeloma：回顾性分析十例有症状的多发性骨髓瘤患者hiv感染多发性骨髓瘤治疗的潜在的治疗效果.pdfVIP

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a retrospective analysis of ten symptomatic multiple myeloma patients with hiv infection a potential therapeutic effect of haart in multiple myeloma：回顾性分析十例有症状的多发性骨髓瘤患者hiv感染多发性骨髓瘤治疗的潜在的治疗效果.pdf

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a retrospective analysis of ten symptomatic multiple myeloma patients with hiv infection a potential therapeutic effect of haart in multiple myeloma：回顾性分析十例有症状的多发性骨髓瘤患者hiv感染多发性骨髓瘤治疗的潜在的治疗效果

Leukemia Research 38 (2014) 1079–1084 Contents lists available at ScienceDirect Leukemia Research j o u rn a l h o m e p ag e: w w w. elsev /locate/leu kres A retrospective analysis of ten symptomatic multiple myeloma patients with HIV infection: A potential therapeutic effect of HAART in multiple myeloma Geling Li a , Robert D. Lewis b , Nidhi Mishra b , Constantine A. Axiotis a,∗ a Department of Pathology, SUNY Downstate Medical Center, Kings County Hospital Center, Brooklyn, NY, United States b Department of Haematology/Oncology, SUNY Downstate Medical Center, Kings County Hospital Center, Brooklyn, NY, United States a r t i c l e i n f o a b s t r a c t Article history: The impact of highly active anti-retroviral therapy (HAART) in multiple myeloma (MM) is unknown. Ten Received 1 May 2014 HIV+ and 28 HIV-negative patients were retrospectively identiﬁed out of 262 cases of MM diagnosed Received in revised form 19 June 2014 at Kings County Hospital Center since the introduction of HAART in 1996. The HIV+ MM patients on Accepted 6 July 2014 HAART had superior overall survival (OS) (Fisher exact, p = 0.008; log-rank, p = 0.012) and progression Available online 14 July 2014 free survival (PFS) (Fisher exact, p = 0.007; log-rank, p = 0.009) than the HIV-negative MM patients. HAART alone blocked the production of serum M-protein. We propose that HARRT should be explored for the Keywords: