云克治疗绝经后型糖尿病并骨质疏松症患者疗效观察.pdfVIP

摘 要 云克治疗绝经后2型糖尿病并骨质疏松症 患者疗效观察 研究生：高 荣 导师：葛家璞 摘 要 目的：探讨锝亚甲基二磷酸盐针剂联合碳酸钙D3片、骨化三醇胶丸治疗绝经后2 型糖尿病并骨质疏松症患者的疗效。方法：诊断明确的绝经后2型糖尿病并骨质疏松 症患者31例为治疗组，其中汉族19例，维吾尔族12例。予以每日静脉滴注锝亚甲基 二膦酸盐针剂15 日，联合口服碳酸钙D3片、骨化三醇胶丸，持续6月。同时选取绝经 后2型糖尿病并骨质疏松症患者28例为对照组，其中汉族14例，维吾尔族14例，年龄、 糖尿病病程及绝经年限均与治疗组匹配，常规口服碳酸钙D3片、骨化三醇胶丸，疗 程均为6月。测定两组治疗前后的骨密度、血清碱性磷酸酶、肝功、肾功及骨代谢指 标，并进行组间对比。结果：治疗组6个月后临床症状改善，云克治疗组疗效明显优 于对照组，总有效率93.5% ；与对照组的各部位平均骨密度值比较差异有统计学意义 (P0.05) 。左前臂桡尺骨远端1/3交界处、腰椎及股骨颈骨密度(BMD)增幅分别达 4.3% 、2.8%,3.2% 。与治疗前相比血清碱性磷酸酶降低，差异有统计学意义。治疗前 后血清肝肾功无明显变化。结论：云克联合钙尔奇D片、盖三淳胶丸治疗绝经后女性 2型糖尿病并骨质疏松症有效且安全。 关键词：绝经后女性；2型糖尿病并骨质疏松症；锝亚甲基二膦酸盐；碳酸钙D3片； 骨化三醇胶丸 —1— 新疆医科大学医学硕士论文 Efficacy of Technetium[99Tc] Methylenediphosphonate treated in the type 2 diabetic patients with postmenopausal osteoporosis Postgraduate:Gao Rong Tutor:Ge Jiapu Abstract Objective:To explore the Efficacy of Technetium[99Tc] Methylenediphosphonate combined with administration of calcium tablet and calcitriol, treated in the type 2 diabetic patients with postmenopausal osteoporosis. Method:we recruited 31 type 2 diabetic patients nequivocally diagnosed of postmenopausal osteoporosis as treatment group (race: Han=19, Urger=12), who were given Technetium[99Tc] Methylenediphosphonate intravenously Every day. At same time, matched with age, duration of type 2 diabetes, duration of postmenopause, we set up a control group (N=28, race: Han=14, Urger=14). calcium tablet and calcitriol were administered as basic therapy of two groups. The therapy went on for 6 months. Evaluating indexes, including bone mineral density(BMD), alkaline phos