美罗培南不同静输注方式对cvvh患者％t＞mic的影响.pdfVIP

肿Fll r l llflII IIIIII III Y1 733633 输注、静脉持续输注同样安全、有效；当致病菌MIC为即酽mL-1时，美罗培南0．59q8h 建议3h静脉输注或者持续输注；当致病菌MIC≥1似酽mL-1时，推荐增大给药剂量或 者更换其它抗菌药物治疗。 硕士研究生 宋蕾(护理学) 指导教师 孙运波 教授 关键词：美罗培南；静脉输注：血药浓度；连续性静脉一静脉血液滤过； 药代动力学参数／药效学 Abstract A and method Object high simple，preciserapid perfomanceliquidchromatographic hasbeen forthedeterminationof inhumanserum．Thismethod developed meropenem wasusedtomeasure concentrationof with meropenem’Splasma patientCVVH．By minutes hours PK／PD oftraditional30 infusion，3 comparingmeropenem’Sparameter infusionandcontinuous choosethebesttreatment infusion，we protocols． Method forthemeasurementof UsingHighperfomanceliquidchromatograiphy concentrationof inserum．WeuseVenusilMPC18 Meropenem chromatographic mobileconsistedof10．53mmolL-1ammonium column(250mmx4．6mm；靴m)，thephase acetic offlow 4)with acid，thevelocity acetate—acetonitrile(90：05，V／V)(pHglacial being UVdetectionwasat298 thestandard 1．0ml‘min-1，The nm．Drawing CHile，determinating the rateandthe of the concentrationof recovery degreeprecison，detectingplasma CVVH whichweretreated threedifferentinfusionof