两个高度近视家的排除定位和全基因组连锁研究
Abstract
Ex,:lusive andand dde OI。’
mapPinkppinggenome-wiaelinkaglinkageStUdy
11 m
twofamiliesilieswith
lli2h0Pla
owtaipoyhighm
Lei
Tian
Postgraduate
TutorJinXuemin
of
DepartmentOphthalmology
ThefirstAffiliated of
HospitalZhengzhouUniversity
Henan(450052)
Zhengzhou
Abstract
ective
Obj
To the betweentwo andsixknown
identify highmyopiapedigrees
relationship
included the chromosomal
loci,which potential
hi曲myopia ZNF644.Mapping
wherethecausalmutations themutationsinthe
region locate;thenscreening mapped
toidentifiedthenewcausal asto evidencesofthe
linkageregion gene,SO provide
molecularlevelfor themechanismof
clarifing highmyopia.
Method
inheritance
whichmeettheruleofautosomaldominant
Highmyopiapedigrees
werecollected.Primersof ZNF644were PrimerPremier5.
gene designedby
ZNF644forthetwo intwo were
gene probandshighmyopiapedigreesamplifiedby
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