两个高度近视家的排除定位和全基因组连锁研究.pdf

两个高度近视家的排除定位和全基因组连锁研究.pdf

两个高度近视家的排除定位和全基因组连锁研究

Abstract Ex,:lusive andand dde OI。’ mapPinkppinggenome-wiaelinkaglinkageStUdy 11 m twofamiliesilieswith lli2h0Pla owtaipoyhighm Lei Tian Postgraduate TutorJinXuemin of DepartmentOphthalmology ThefirstAffiliated of HospitalZhengzhouUniversity Henan(450052) Zhengzhou Abstract ective Obj To the betweentwo andsixknown identify highmyopiapedigrees relationship included the chromosomal loci,which potential hi曲myopia ZNF644.Mapping wherethecausalmutations themutationsinthe region locate;thenscreening mapped toidentifiedthenewcausal asto evidencesofthe linkageregion gene,SO provide molecularlevelfor themechanismof clarifing highmyopia. Method inheritance whichmeettheruleofautosomaldominant Highmyopiapedigrees werecollected.Primersof ZNF644were PrimerPremier5. gene designedby ZNF644forthetwo intwo were gene probandshighmyopiapedigreesamplifiedby

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