明日叶查尔酮对型糖尿病大鼠血管损伤的影响.pdfVIP

II I IIIILIIIlU 哪IIIIIIIII Y2338937 对照组降低，差异有统计学意义(P0．05)。 结论：明日叶查尔酮可降低2型糖尿病大鼠血清中ET一1、VE—Ca和CRP等的含量， 提高SOD的表达水平，起到抑制血管损伤的作用。 硕士研究生：张照杰(卫生毒理学) 指导教师：钟进义教授张华强教授 关键词：明日叶查尔酮；内皮素；钙粘蛋白；C一反应蛋白；2型糖尿病 EFFECT OFASHITABACHALCoNEoNVASCULARIN胍YoF TYPE2DIABETESRATS ABSTRACT the actionofAshitabaChalcone lABSTRACT】Objective：To investigateprotective vascularof 2diabetesrats．Methods：The2diabetesofratswas (AC)on injury type type induced with as ectionwellaswith diet bystreptozotocinintraperitoneal inj high-fat ratswere 4 feeding．The dividedinto with10ratsineach randomly groups group，diabetic control AC AC andlow—doseAC group，high—dosegroup，middle—dosegroup group。 Diabeticcontrol werefed fat group byhigh dietand withdistilledwater． gavaged withdiabeticcontrol andlowdose Compared group，high、middleAC were groups withAC30、10and ratsof normalcontrol supplemented 5mg／kgperdayrespectively．The werewitll fed normaldietfoodand withdistilledwater．Afterfour group