肾气丸与右归丸肾虚大鼠肾脏细胞凋亡及肾组织内bc1-2、fas表达的影响.pdf

E x P lo r e th e sh en q i P ills a n d y o u g u i P ills to th e in flu en ee o f ki d n ey d eficien ey ra ts ab o u t ki d n ey eell a P o P to sis a n d ex P ressio n o f g en e b e l一2 a n d fa s in th e ki d n ey tissu e s SP eeiality :T C M elin ie basis一JinG u iy aoL u e A u thor :Q iL ijuan T u to r :P ro f.Ta o H a llh u a A b str a Ct o bjeetiv e:E xP lore the D iffe rent M eehanism s betww en ShenQ I P ills and Yo uG ui b o lu s fro m th e m o leeu lar b io lo gy lev e l aceord in g to th e re seareh ab ou t b el一2 ，fas g en e exP ressio n o f ren al eell aP oPto sis in rat k idn ey tissu e w ith k idn ey d efieien ey eau sed b y “F atigu e an d S ex u a l stra in P lu s g eniam ie in ”.M eth o d s : ”F atigu e an d S ex u a l stra in P lu S g en tam ie in ”R at K id n ey M o d e l L aw an d S h en q i P ill，YO u G u i P ill gro u P th er即 y，lab o - rato ry rats w ere m ea su red serum ereatin in e ，b lo o d urea n itro g en a fter th e 一en d o f ex P ire- m en t，T U N E L d eteetio n o f ap o P to sis ，Im m u n o h isto eh em ica l d eteetio n o f ren a l tissu e ex P re ssio n o f b el一2 an d fas.R esu lts : 1. M o d e lin g 15 eo m P lete ，k id n ey d efieien ey sy m P - tom s aP P ear in the m o d e l，m a in ly fat ig u e，listle ssn ess，after sw irnm in g w ith a etiv e eo - n g e stio n ，a etiv e lo w ， eo ld eh ills，fur 15 n o t sh in y ，th in sto o l. 2 . R en a l fun etion w a s ex - am ined serum aPP ears B IJN (b lood ure a n itrogen)，C r (ereatin ine) w as sign ificantly in crea sed ，in d ieatin g th e m o d e l w a s su eee ssfu l.A fter treatm en t，C ]几B U N h av e to resu m e th e tren d . 3 . A P o P to sis T l加 E L sh ow ed