SNParrayandLeukemiaKingMedMaoLinlin.pptVIP

CLL FISH 探针 CEP 12 probe-Green QC ABBOTT * n=255 (198 untreated, 57 relapsed ) Affymetrix SNP array Elevated CLL genomic complexity as an independent marker Aggressive CLL and short survival High risk subgroup：≥2 CNAs (40% of all CLL) CLL-基因组拷贝数变异谱 (一) * CLL-基因组拷贝数变异谱 (二) n=353 144-paired sample Affymetrix SNP array 1.8 CNVs/Patient 60% patients-no CNVs * CLL del13q14亚类-SNP array FISH结果无法区分Ⅰ型或Ⅱ型 Malek SN et al. Oncogene 2013, 32:2805-2817. * del13q14 Ⅱ型与不良预后相关 Parker H et al. Leukemia?2011, 25(3):489-497. 13q deletion anatomy and disease progr