黛力新与舍曲林联合治疗卒中后抑郁的效果观察.docVIP

黛力新与舍曲林联合治疗卒中后抑郁的效果观察 　　【摘要】 目的：观察黛力新与舍曲林联合应用对卒中后抑郁（中度以上）的临床疗效。方法：选择2013年7月-2014年11月，年龄60岁以上在笔者所在医院神经科门诊及住院的卒中后抑郁患者，进行汉密尔顿抑郁量表（HAMA）测定，选取HAMA得分在20分以上人群共77例，按照随机数字表法分为治疗组与对照组，其中治疗组40例，给予黛力新、舍曲林联合抗抑郁治疗；对照组37例，仅给予舍曲林干预。访视治疗6个月，对治疗前，治疗1、3、6个月时进行HAMA评分，记录结果并进行统计学分析。结果：对照组与治疗组在治疗1个月后，两组HAMA评分比较，差异有统计学意义（t=-3.826，P=0.001）；治疗3个月后，两组HAMA评分比较，差异有统计学意义（t=-3.158，P=0.004）；治疗6个月后，两组HAMA评分比较，差异有统计学意义（t=-5.165，P=0.000）；治疗组药物干预1、3、6个月后，其HAMA得分改善明显优于对照组，差异均有统计学意义（P中国论文网 /6/view-7248331.htm 　　【关键词】 卒中后抑郁； 黛力新； 神经康复 　　中图分类号 R743 文献标识码 A 文章编号 1674-6805（2016）3-0001-03 　　Effect of Deanxit Combined with Sertraline on Patients with Post Stroke Depression/KONG Ling-hua，LU Yan，CHENG Su-zhen.//Chinese and Foreign Medical Research，2016，14（3）：1-3 　　【Abstract】 Objective：To observe the clinical effect of Deanxit combined with Sertraline on patients with post stroke depression（PSD） moderate or above.Method：From July 2013 to November 2014 77 cases over 60 years old with PSD moderate or above outpatient and inpatientin in neurology of our hospital which the Hamilton Anxiety scale（HAMA） were scored more than 20 points were randomly divided into two groups：the treatment group and the control group.The treatment group was given Deanxit combined with Sertraline for antidepressant treatment，while the control group was given Sertraline only.Visit 6 months，the HAMA scale were assessed and recorded for statistical analysis before and after one month，three months，six months treatment.Result：HAMA score comparison of the treatment group and the control group after one month treatment，there was statistical significance（t=-3.826，P=0.001）.After three months treatment，there was statistical significance（t=-3.158，P=0.004）.After six months treatment，there was statistical significance（t=-5.165，P=0.000）.HAMA score improved of the treatment group was better than that of the control group after one month，three months and six months treatment，it showed statistically significant difference（P 　　1 资料与方法 　　1.1 一般资料 　　选择2