普罗布考联合阿托伐他汀在急性脑梗死患者中的应用效果.docVIP

普罗布考联合阿托伐他汀在急性脑梗死患者中的应用效果 　　[摘要] 目的 观察急性脑梗死患者应用普罗布考联合阿托伐他汀的疗效及复发情况。 方法 收集2010年1月～2012年11月于辽宁省金秋医院入院的初次患前循环急性脑梗死且经颈动脉超声检查存在颈动脉粥样硬化不稳定性斑块患者120例，将其随机分为观察组及对照组。观察组给予普罗布考联合阿托伐他汀治疗；对照组给予单纯阿托伐他汀治疗。观察两组患者治疗后血脂水平、颈动脉斑块检出率、斑块积分情况及脑梗死复发情况。 结果 两组治疗后血脂水平（TG、CHOL、LDL-C）下降，较治疗前差异有统计学意义（P0.05）；两组治疗后颈动脉不稳定斑块检出率降低，不稳定斑块积分降低，观察组低于对照组，差异有统计学意义（P中国论文网 /6/view-7216648.htm 　　[关键词] 急性脑梗死；普罗布考；阿托伐他汀；不稳定斑块 　　[中图分类号] R972+.6 [文献标识码] A [文章编号] 1674-4721（2016）02（a）-0135-04 　　Effect of atorvastatin combined with atorvastatin in patients with acute cerebral infarction 　　ZHANG Shu-yan ZHAO Qian SUN Shu-ning LIU Li-jiao 　　Department of Internal Medicine-Neurology，Jinqiu Hospital of Liaoning Province，Shenyang 110016，China 　　[Abstract] Objective To observe the therapeutic effect and recurrence with combined therapy of probucol with atorvastatin for patients with acute cerebral infarction. Methods From January 2010 to November 2012，120 patients admitted in the Jinqiu Hospital of Liaoning Province by reason of acute anterior circulation infarction with vulnerable plaque by carotid ultrasound at the first time were randomly assigned to observation group and control group.The observation group was treated with probucol combined with atorvastatin.At the same time the control group was only treated with atorvastatin.The serum level of lipid，detection rates of carotid plaque，scores of plaque and recurrence of cerebral infarction were observed. Results After treatment，the levels of TG，CHOL and LDL-C between two groups was significantly decreased respectively，with statistical difference（P0.05）.After treatment both detection rates and scores of carotid vulnerable plaque for the observation group was significantly decreased than that of the control group respectively，with statistical difference（P 　　[Key words] Acute cerebral infarction；Probucol；Atorvastatin；Vulnerable plaque 　　目前我国脑血管病发病率逐年呈上升趋势，且发病年龄逐渐呈年轻化，致死率及致残率高，给患者及其家庭带来极大的痛苦及经济负担，而脑梗死作为常见的脑血管病之一，积极预防及治疗是非常必要的。颈动脉粥样硬化为缺血性脑卒中的危险因素，粥样硬化斑块的破裂可形成栓子易导致血管阻