早期应用纳络酮治疗颅脑损伤并脑疝开颅术后患者的效果初评.docVIP

早期应用纳络酮治疗颅脑损伤并脑疝开颅术后患者的效果初评 　　【摘要】 目的：探讨早期应用纳络酮治疗颅脑损伤并脑疝开颅术后患者的效果。方法：收集2013年2月-2014年5月笔者所在医院颅脑损伤并脑疝开颅术后的100例患者，按住院单双号顺序分为研究组和对照组，各50例。对照组行常规治疗，研究组在对照组基础上加用纳络酮治疗。观察比较两组术前、术后3 d、术后7 d格拉斯哥昏迷评分，治疗后3个月临床神经功能评分，术后死亡率和住院时间。结果：两组术前格拉斯哥昏迷评分结果比较，差异无统计学意义（P0.05）；两组术后3 d、术后7 d格拉斯哥昏迷评分结果比较，差异均有统计学意义（P中国论文网 /6/view-7245152.htm 　　【关键词】 早期； 纳络酮； 颅脑损伤； 脑疝； 开颅术； 效果 　　中图分类号 R651.15 文献标识码 A 文章编号 1674-6805（2015）35-0001-02 　　Early Application of Naloxone in the Treatment of Craniocerebral Injury and Evaluation of Patients with Cerebral Hernia after Craniotomy/LIU Chao，HAN De-qing，YUAN Wen.//Chinese and Foreign Medical Research，2015，13（35）：1-2 　　【Abstract】 Objective：To investigate the effect of early application of Naloxone in the treatment of craniocerebral injury and cerebral hernia patients after craniotomy effect.Method：100 patients with craniocerebral injury and cerebral hernia craniotomy in our hospital from February 2013 to may 2014 were colected， according to the length of single sequence，they were divided into the study group and the control group，50 cases in each group.The control group received routine treatment， while the study group was treated with Naloxone on the basis of the control group.The Glasgow coma score of before surgery，the 3 days and 7 days after the operation，clinical neurological function score after 3 months of treatment，postoperative mortality and length of hospital stay，which were observed and compared with the two groups.Result：Before surgery，the Glasgow coma score in the two groups were compared，there was no statistically significant difference（P0.05）；the results of 3 days and 7 days after operation were compared of the two groups，the differences were statistically significant（P 　　First-authors address：Zhuzhou Central Hospital，Zhuzhou 412000，China 　　doi：10.14033/ki.cfmr.2015.35.001 　　颅脑损伤是因暴力直接或间接作用于头部引起颅脑组织的损伤，若不在第一时间抢救，死亡率非常高。颅脑外伤后急需对患者进行开颅手术，目的是减轻颅内高压、清除血肿。并且配合脱水、营养神经、改善酸中毒及纠正电解质紊乱的药物治疗。纳络酮为阿片受体的非特异性拮抗剂，能减少脑脊液中的炎性反应，抑制蛋白水解和神经细胞凋亡，减少患者的昏迷时间[1]。因此收集