聚乙烯基吡咯烷酮翻译1.doc

Advanced Pharmaceutical Bulletin, 2013, 3(1), 217-225 doi: /10.5681/apb.2013.036 http://apb.tbzmed.ac.ir/ Formulation,CharacterizationandPhysicochemicalEvaluatin of Potassium Citrate Effervescent Tablets Abolfazl Aslani*, Fatemeh Fattahi Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 配方、特性和物理化学评价柠檬酸钾泡腾片阿布Aslani ,今天Fattahi制药学、制药和新型给药系统研究中心,伊斯法罕大学医学科学,伊斯法罕、伊朗 A R T I C L E I N F O A B S T R A C T Article Type: Research Article Purpose: The aim of this study was to design and formulation of potassium citrate effervescent tablet for reduction of calcium oxalate and urate kidney stones in patients suffering from kidney stones. Methods: In this study, 13 formulations were prepared from potassium citrate and effervescent base in different concentration. The flowability of powders and granules was studied. Then effervescent tablets were prepared by direct compression, fusion and wet granulation methods. The prepared tablets were evaluated for hardness, friability, effervescent time, pH, content uniformity. To amend taste of formulations, different flavoring agents were used and then panel test was done by using Latin Square method by 30 volunteers. Results: Formulations obtained from direct compression and fusion methods had good flow but low hardness. Wet granulation improves flowability and other physicochemical properties such as acceptable hardness, effervescence time ≤3minutes, pH6, friability 1%, water percentage 0.5% and accurate content uniformity. In panel test, both of combination flavors; (orange - lemon) and (strawberry - raspberry) had good acceptability. Conclusion: The prepared tablets by wet granulation method using PVP solution had more tablet hardness. It is a reproducible process and suitable to produce granules that are compressed into effervescent tablets due to larger agglomerates. Article History: Received: 7 November