双联抗血小板聚集联合强化降脂治疗伴基底动脉狭窄的后循环梗死.docVIP

双联抗血小板聚集联合强化降脂治疗伴基底动脉狭窄的后循环梗死 　　【摘要】 目的：研究阿司匹林、氯吡格雷双联抗血小板聚集联合阿托伐他汀钙强化降脂治疗伴基底动脉狭窄的后循环梗死的效果。方法：50例伴基底动脉狭窄的后循环梗死患者随机分组，对照组给予抗血小板聚集及常规降脂治疗；观察组给予双联抗血小板聚集及强化降脂治疗。疗程均为3周。在治疗前和治疗后1、2、3周分别进行神经功能缺损程度评分（NIHSS）。结果：观察组的有效率92.0%，观察组对神经功能缺损的治疗效果优于对照组（P0.01）。两组患者均没有发生严重出血情况及肌肉疼痛情况。结论：短时间应用阿司匹林、氯吡格雷双联抗血小板聚集联合强化降脂对伴基底动脉狭窄的后循环梗死治疗效果优于单独使用阿司匹林及常规降血脂组，且不会发生严重的出血事件。 　　【关键词】 双联抗血小板； 强化降脂； 基底动脉狭窄； 后循环梗死 　　【Abstract】 Objective： To study the curative effect of dual antiplatelet aggregation and intensive lipid lowering on posterior circulation infarction patients with basilar artery stenosis. Method： Fifty posterior circulation infarction patients with basilar artery stenosis were randomly allocated into control group and observation group. Patients in the control group were treated by antiplatelet aggregation and conventional lipid lowering treatment. Observation group was given dual antiplatelet aggregation and intensive lipid lowering treatment. Course of treatment lasted three weeks. National Institutes of Health Stroke Scale （NIHSS） was tested before therapy and after the treatment of 1， 2， 3 weeks. Result： Efficiency was 92.0% in the observation group， nerve function defect treatment effect of the observation group was better than that of the control group （P0.01）. Both of the two groups had no severe hemorrhage and muscular aches. Conclusion： Short time of aspirin， clopidogrel dual antiplatelet aggregation combined with intensive lipid lowering treatment on posterior circulation infarction patients with basilar artery stenosis is better than aspirin alone and conventional lipid lowering group； and no severe hemorrhage happens. 　　【Key words】 Dual antiplatelet； Intensive lipid lowering； Basilar artery stenosis； Posterior circulation infarction 　　First-author’s address： People’s Hospital of Shimen County， Shimen 415300， China 　　doi：10.3969/j.issn.1674-4985.2015.13.011 　　伴有基底动脉狭窄的后循环梗死多为血栓形成所致的脑梗死，是后循环梗死的高危情况，患者病情进展快，易发生进展性卒中，功能预后差，常规治疗方法往往疗效不佳，是缺血性脑血管病治疗中的一大难点，其与基底动脉硬化、狭窄、斑块形成、