小承气汤与厚朴三物汤的药理作用分析和临床研究.docVIP

小承气汤与厚朴三物汤的药理作用分析和临床研究 　　摘要：目的：探讨小承气汤与厚朴三物汤的药理作用分析和临床研究。方法：以健康的大鼠作为研究对象，体重约250g左右，雌雄不限，共100 只，按随机数字表法将100只小鼠分成4组，每组 25只，定义为A组、B组、C组、D组。选取A组、B组并禁食12小时，然后给予复方地芬诺酯 10mg/kg，在服用后2小时制备成便秘模型。然后对A组、B组大鼠进行喂服含有墨汁染黑的小承气汤（2g/kg）或厚朴三物汤（2g/kg），并添加正常大鼠食料与纯净水。观察A组、B组大鼠首次黑便排出时间及6小时内黑便排出点数。对C组、D组大鼠服用0.015%氨水5ml，在服用后立即给予服用小承气汤（2g/kg）或厚朴三物汤（2g/kg）。观察C组、D组大鼠咳嗽潜伏期及咳嗽次数。结果：A组与B组首次排便时间、6小时内黑便排出点数分别为（122.7±32.4分钟、5.9±2.4点）、（74.5±52.3分钟、3.4±2.7点），差异有统计学意义（P0.05）；C组、D组大鼠咳嗽潜伏期及咳嗽次数分别为（85.8±12.7秒、62.4±12.9次）、（96.5±10.5秒、56.9±13.5次），差异有统计学意义（P0.05）。结论：本次研究认为小承气汤泻下作用强，厚朴三物汤止咳作用明显。 　　关键词：小承气汤；厚朴三物汤 ；泻下 ；止咳 　　Abstract ：To investigate the clinical study of small Dachengqitang and Magnolia three things soup analysis and pharmacological effects. Methods： healthy rats as subjects， weighing about 250g or so， male or female， a total of 100， according to a random number table 100 mice were divided into four groups， each 25， defined as group A and group B group C， D groups. A select group B and fasted for 12 hours， then give compound diphenoxylate 10mg / kg， in the two hours after taking the model prepared constipation. Then the group A and group B rats were fed ink to black suits contain small Dachengqitang （2g / kg） or Magnolia officinalis three Wu-Tang （2g / kg）， and add the normal rats diets with pure water. Observed in group A and B will be discharged black rats first time and will be discharged within six hours of black dots. For group C， D group were administered 0.015% ammonia 5ml， given after taking taking small Dachengqitang （2g / kg） or Magnolia officinalis three Wu-Tang （2g / kg） immediately. Observation group C， D group were cough cough latency and number. The results： A group and B group first defecation time will be discharged within six hours of black dots， respectively （122.7 ± 32.4 分钟， 5.9 ± 2.4 points）， （74.5 ± 52.3 分钟， 3.4 ± 2.7 points）， the difference was statistically significant （P 0.05）； group C， group D rats cough cough latency and the number was （85.8 ± 12.7 秒， 62.4 ± 12.9