强直性脊柱炎生存质量及活动影响因素探讨.docVIP

强直性脊柱炎生存质量及活动影响因素探讨 　　[摘要] 目的 探讨强直性脊柱炎（AS）患者生存质量与患者活动功能状态、血沉（ESR）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）的相关关系。 方法 选择2010年2月～2013年4月我院收治的95例强直性脊柱炎患者作为研究对象。应用收集资料、调查问卷的方式对所有研究对象BASDAI、BASFI分数进行评估，并与患者枕墙间距离、指地距离、胸廓活动度、实验室指标（ESR、CRP、TNF-α）的相关性和多元线性回归进行分析。 结果 BASDAI与BASFI间存在密切联系，BASDAI与枕墙间距离、指地距离、胸廓活动度、CRP、TNF-α、修订Schober试验有明显相关性（P0.05）；BASFI与枕墙间距离、指地距离、胸廓活动度、TNF-α、CRP、修订Schober有明显相关性（P0.05）。强直性脊柱炎患者BASDAI、BASFI多元线性回归分析表明，CRP、TNF-α、修订Schober试验均是强直性脊柱炎患者生存质量和活动的影响因素，差异均有统计学意义（P0.05）。 结论 AS疾病活动和AS功能间存在密切联系，修订Schober试验、CRP、TNF-α可反映患者的功能活动，为指导临床治疗和预后恢复提供可靠的理论依据。 　　[关键词] 强直性脊柱炎；生存质量；活动；影响因素 　　[中图分类号] R593.23 [文献标识码] B [文章编号] 1673-9701（2015）16-0080-03 　　[Abstract] Objective To discuss the relationship of life quality and active function state， erythrocyte sedimentation （ESR）， tumor necrosis factor-α （TNF-α） and C-reaction protein （CRP） of patients with ankylosing spondylitis （AS）. Methods A total of 95 cases of patients with AS received and cured in our hospital during the period from Feb 2010 to April 2013 were selected as research objects. The BASDAI and BASFI scores of all research objects were evaluated by collecting information and questionnaires， and its relations with distance between the pillow wall， distance between the ground， thoracic activity， laboratory indexes（ESR， CRP and TNF-α） and multiple linear regression were analyzed as well. Results BASDAI and BASFI had close relation， while BASDAI had obvious relations with distance between the pillow wall， distance between the ground， thoracic activity， CRP， TNF-α and amended Schober test （P0.05）. The analysis on multiple linear regression of BASDAI and BASFI showed that CRP，TNF-α and amended Schober test were all the influence factors of life quality and activity factors of patients with AS， and with statistical differences（P0.05）. Conclusion Disease activities and function of AS have close relation， and amended schober test， CRP and TNF-α can influence the functional activities of patients， which provide the reliable theo