比较不同剂量辛伐他汀治疗老年冠心病高脂血症患者的效果.docVIP

比较不同剂量辛伐他汀治疗老年冠心病高脂血症患者的效果 　　【摘要】 目的：观察不同剂量的阿托伐他汀治疗老年冠心病高脂血症的疗效及机制。方法：采集本院临床120例患者分为观察组和对照组，两组均进行基础治疗，对照组在此基础上给予辛伐他汀阿托伐他汀60 mg/d，1次/d，观察组给予辛伐他汀阿托伐他汀40 mg/d，1次/d。观察两组患者血脂水平。结果：给药后，两组血脂水平均出现明显降低，观察组效果更为显著，两组比较差异有统计学意义（P0.05）。观察组不良反应发生情况仅为15.00%，而对照组为66.66%，两组比较差异有统计学意义（P0.05）。结论：给予40 mg剂量的辛伐他汀是治疗老年患者的冠心病合并高脂血症的最为安全有效的常规临床剂量。 　　【关键词】 冠心病； 高脂血症； 辛伐他汀 　　Effect of Simvastatin Treatment for Elderly Coronary Heart Disease Patients with Hyperlipidemia/HUANG Dong-mei.//Medical Innovation of China，2014，11（28）：067-069 　　【Abstract】 Objective： To observe the therapeutic effect and the mechanism of different dose of atorvastatin in treatment of elderly patients with coronary heart disease and hyperlipidemia. Method： 120 cases were divided into observation group and control group， the two groups were treated for infrastructure， control with simvastatin atorvastatin group 60 mg/d on the basis of this， the 1 time/d. The observation group was given simvastatin and atorvastatin 40 mg/d， 1 time/d. To observe changes of blood lipid levels in the two groups. Result： After administration， blood lipid levels of the two groups significantly decreased， the observation group effect was more obvious， with a significant difference between the two groups （P0.05）. The observation group’s the incidence of adverse reactions was only 15%， which was higher than that of the observation group 66.66% （P0.05）. Conclusion： 40 mg in doses of simvastatin is the routine clinical dose is safe and effective for the treatment of coronary heart disease in elderly patients with hyperlipidemia. 　　【Key words】 Coronary heart disease； Hyperlipidemia； Simvastatin 　　First-author’s address： Zibo City Combine Traditional Chinese and Western Medicine Hospital， Zibo 255026， China 　　doi：10.3969/j.issn.1674-4985.2014.28.024 　　高脂血症的发病率随着人们的生活水平的提高，大量的进食高脂高蛋白的食物，从而引起高血脂症发病率升高的现象[1]。该病是动脉粥样硬化、脑梗死、肾栓塞及冠心病的诱发因素。冠心病（CHD）中老年人常见的一种心血管疾病，本病的基本病变是供应心肌营养物质的血管冠状动脉发生了粥样硬化而临床中最为多见的为冠心病合并高脂血症的临床情况[2]。尤其是老年人多发，也是由于血脂异常引起冠状动脉粥样硬化的