正常人及单侧突发性聋患者的静息态fMRI 研究.docVIP

正常人及单侧突发性聋患者的静息态fMRI研究 朱新1，黄志纯1，刘斌2，杨明2，季慧1 （东南大学附属中大医院1.耳鼻咽喉-头颈外科；2.放射科，江苏 南京 210009） [摘要] 目的 利用静息态fMRI功能连接的方法观察正常人、左侧突发性聋患者听觉皮层与脑的正相关的功能连接。方法 选取正常人及左侧突发性聋患者分别18例进行静息态fMRI数据采集，用功能连接的方法分别观察正常人及左侧突发性聋患者左右大脑听觉皮层与脑区不同的正相关功能连接脑图, 并比较其差异。结果 正常受试者的有效数据分别以双侧AⅠ区为种子点时，正激活的脑网络主要包含双侧颞横回、颞上回、岛叶、扣带回及辅助运动区。左侧突发性聋患者的有效数据分别以双侧AⅠ区为种子点时，正激活的脑网络类似于正常人，但还是有差别。结论 两组人群以双侧AⅠ区为种子点的听觉系统的功能连接均主要局限于听觉系统之内，耳聋发生后可对该网络产生影响。 [关键词] 　听觉皮层；静息态；功能连接；突发性聋 Normal and unilateral sudden deafness in patients with resting state fMRI study ZHU Xin1,HUANG Zhi-chun1,LIU Bin2,YANG Ming2,JI Hui1 (1.Department of Otolaryngology-Head and Neck Surgery , 2.Department of Radiology , Zhongda Hospital , Southeast University , Nanjing 210009,China ) [Abstract] Objective：Connected to the resting state MRI to observe the normal, the left side of patients with sudden deafness auditory cortex and brain function connection. Methods：Select the normal and the left side of patients with sudden deafness were 18 cases for resting-state functional MRI data collection, using the method of functional connectivity were observed in the left and right auditory cortex of the brain and brain regions in patients with normal and left sudden deafnessrelated functions to connect the brain map, and compare their differences. Results：The effective data of normal subjects, respectively, of AⅠ bilateral seed point, the brain is activated network mainly consists of bilateral transverse gyrus, superior temporal gyrus, insula, cingulate gyrus and supplementary motor area. The effective data of the left side of patients with sudden deafness bilateral region AⅠ seed points, respectively, is activated brain network is similar to normal, but still a difference.Conclusion：The function of the auditory system of two populations of AⅠ bilateral seed point connections are mainly confined to the auditory system, after the occurrence of deafness in this network have an impact.