肥胖与代谢综合征管理[参考].pptVIP

这张图中列出了目前常用的糖尿病治疗药物在降糖、减轻体重和减少内脏脂肪方面的作用情况。从图中可见，与二甲双胍、磺脲、TZD类药物及DPP-4抑制剂相比，GLP-1受体激动剂在这三方面具有非常明显的优势。 * 利拉鲁肽作为人GLP-1类似物，目前已知它可以通过延缓胃排空、抑制胃酸分泌以及刺激中枢中枢神经系统而增加饱食感进而减少能量的摄入，实现减轻体重的作用。 The effect of GLP-1 on weight: GLP-1 affects the gastrointestinal system and delays absorption of food. This is caused by several means, including decreased gastric emptying and acid secretion. For example, the infusion of GLP-1 to generate plasma levels similar to those normally observed following meals delays gastric emptying (Wettergren et al. 1993). Combined, these gastrointestinal effects reduce the meal-relat