老年高血压患者踝肱指数与尾加压素Ⅱ相关性研究.docVIP

老年高血压患者踝肱指数与尾加压素Ⅱ相关性研究 　　【摘要】 目的：研究老年高血压患者踝肱指数与尾加压素Ⅱ（UⅡ）的相关性，进一步探讨UⅡ与动脉粥样硬化的关系。方法：采用放免法测定130例老年高血压患者及72例健康老年人血浆UⅡ浓度，并分别测量踝肱指数（ankle brachial index，ABI），再根据ABI严重程度将高血压患者分为ABI0、ABI1、ABI2三组。结合UⅡ水平、踝肱指数对各组进行比较分析。结果：与健康组比较，高血压患者踝肱指数明显降低，而血浆UⅡ水平明显升高 （P0.01）；高血压患者血浆UⅡ水平与ABI呈明显负相关，高血压三组UⅡ水平组间比较差异有统计学意义（P0.05）。结论：老年高血压患者的踝肱指数与血浆UⅡ水平呈负相关，提示UⅡ浓度与动脉粥样硬化密切相关。 　　【关键词】 高血压； 动脉粥样硬化； 尾加压素Ⅱ； 踝肱指数 　　The Relationship of Ankle-brachial Index and Urotensin Ⅱ in Elderly Patients with Hypertension/CHEN Wei-quan.//Medical Innovation of China，2013，10（14）：137-138 　　【Abstract】 Objective：To study the relationship of ankle-brachial index and urotensin Ⅱ （U Ⅱ）in elderly patients with hypertension， to explore the relationship of U Ⅱ and atherosclerosis. Method：To enroll 130 cases of elderly patients with hypertension and 72 healthy elderly，the plasma U Ⅱ concentration and the ankle-brachial index （ankle brachial index， ABI） was measured by radioimmunoassay in all cases.According to the severity of the ABI，the hypertensive patients were divided into ABI0 /ABI1/ ABI2 three groups. At last， a comprehensive analysis of U Ⅱ level， ankle-brachial index， in each group was deployed.Result：Compared with the healthy individuals， the ankle-brachial index in hypertensive patients was significantly reduced， in contrast the plasma U Ⅱ levels were significantly increased （P0.01）.The plasma U Ⅱ level was negatively related to the ABI in hypertensive patients.The difference of U Ⅱ level in three hypertensive groups was statistically significant （P0.05）.Conclusion：ABI in elderly hypertensive patients is negatively related with the plasma U Ⅱ level and the concentration of U Ⅱ is closely related to the Atherosclerosis. 　　【Key words】 Hypertension； Artery atherosclerosis； Urotensin Ⅱ； Ankle-brachial index 　　First-author’s address：Luoding People’s Hospital， Luoding 527200，China 　　doi：10.3969/j.issn.1674-4985.2013.14.079 　　动脉粥样硬化（AS）是多种因素引起的一种连续性、全身性疾病，是心脑血管疾病的致病基础，其中高血压病是其独立危险因素。研究发现，ABI可作为反映动脉硬化的敏感特异性指标之一