小剂量地塞米松对新生儿胎粪吸入综合征患儿血清IL—5、IL—13和TNF—α的影响.docVIP

小剂量地塞米松对新生儿胎粪吸入综合征患儿血清IL—5、IL—13和TNF—α的影响 　　[摘要] 目的 探讨小剂量地塞米松对新生儿胎粪吸入综合征患儿血清中白介素-5（IL-5）、白介素-13（IL-13）和肿瘤坏死因子-α（TNF-α）的影响。 方法 新生儿胎粪吸入综合征患儿40例，随机分为治疗组和对照组，除了治疗组从第1、2、3天加用小剂量地塞米松[0.5 mg/（kg·d）]治疗外，两组其余治疗方案均相同；以足月顺产的正常新生儿20例作为正常组。检测3组研究对象第1、4、7天血清IL-5、IL-13、TNF-α的变化。 结果 对照组第1、4、7天血清IL-5、IL-13、TNF-α水平均高于正常组（P 0.05）；对照组和治疗组第4天血清IL-5、IL-13、TNF-α明显升高，且对照组的水平高于治疗组（P 0.05）。 结论 在新生儿胎粪吸入综合征患儿治疗过程中，小剂量地塞米松可抑制炎症反应，减轻气道高反应性。 　　[关键词] 新生儿；胎粪吸入综合征；地塞米松；白细胞介素-5；白细胞介素-13；肿瘤坏死因子-α 　　[中图分类号] R722 [文献标识码] A [文章编号] 1674-4721（2013）06（c）-0031-02 　　Effect of the low-dose dexamethasone on the level of IL-5，IL-13，TNF-α in blood of newborn meconium aspiration syndrome 　　HUANG Shangming YUAN Yi XIAO Wanxiang▲ CHEN Rui 　　Shenzhen Baoan Maternal and Child Health Hospital，Guangdong Province，Shenzhen 518100，China 　　[Abstract] Objective To investigate the effect of low-dose Dexamethasone on the level of IL-5，IL-13，TNF-α in blood of newborn meconium aspiration syndrome. Methods 40 cases of neonatal meconium aspiration syndrome were randomly divided into treatment group and control group.Two groups were given the same treatment，except the treatment group from the three days of being hospitalized with a small dose Dexamethasone treatment.In addition，20 cases of normal neonates were taken as normal control group.The level of IL-5，IL-13，TNF-α in blood were determined at the first day，the fourth day，the seventh day，respectively. Results The level of IL-5，IL-13，TNF-α in control group were higher than in the normal control group （P 0.05） at the first day，the fourth day，the seventh day.At the fourth day，the level of IL-5，IL-13，TNF-α in treatment group and control group increased obviously and were higher than in the normal control group （P 0.05）. Conclusion In neonates with meconium inhaled syndrome treatment process，dexamethasone can inhibit the inflammatory response and reduce airway high inflammatory reaction. 　　[Key words] Newborn；Meconinum aspiration syndrome；Dexamethasone；Interleukin-5；I