ppt课件-nucleicacidtestingvsinfectivity.pptVIP

Nucleic Acid Testing vs Infectivity Michael P. Busch, M.D., Ph.D. Blood Centers of the Pacific Blood Systems, Inc. EPFA, Lisbon Portugal May, 2001 NAT vs Infectivity Overview of stages of infections and importance of understanding stage-specific gEq:infectivity ratios (concentration vs volume infused) Review of NA dynamics (pre/peri/post-SC) for HIV, HCV and HBV Review infectivity data for each stage Need for future studies animal transmission models lookback studies (NAT/SC donors; recipient cases) Stages of TTVIs and infectivity Pre-ramp-up viremia Ramp-up viremia Plateau phase / peak v