hypoglycaemiaininfantsandchildren aetiology（hypoglycaemiaininfantsandchildren病因学）.doc

Short Title: Hypoglycaemia in infants and children: Aetiology, investigation and treatment Full Title: Guideline for the management of hypoglycaemia in infants, children and young people: Aetiology, investigation and treatment Date of production/Last revision: Nov 2007 Explicit definition of patient group to which it applies: This guideline is intended for infants outside of the neonatal period (i.e. 28 days) children and young people up to the age of 19 years who do not have a diagnosis of diabetes or other established metabolic disorder. Name of contact author Dr Becky Smith, Paediatric SpRDr Tabitha Randell, Consultant Paediatrician Ext: Revision Date Nov 2010 This guideline has been registered with the Trust. However, clinical guidelines are guidelines only. The interpretation and application of clinical guidelines will remain the responsibility of the individual clinician. If in doubt contact a senior colleague or expert. Caution is advised when using guidelines after the review date. Hypoglycaemia in infants and children: Aetiology, investigation and treatment Scope of Guideline This guideline is intended for infants and children outside of the neonatal period (i.e. 28 days) who do not have a diagnosis of diabetes or other established metabolic disorder. There is a separate neonatal guideline available from the Neonatal Unit. Definition Hypoglycaemia refers to the inadequacy of circulating levels of blood glucose and is defined as a laboratory blood glucose measurement of 2.6mmol/l. Hypoglycaemia may be associated with clinical symptoms and signs or be asymptomatic. Background Hypoglycaemia in children beyond the neonatal period is relatively common accounting for 1 in 500 hospital admissions. The majority of these will be in patients with known diabetes. In children with no previously identified cause for hypoglycaemia up to 30% of cases are due to defects in fatty acid oxidation. Prolonged or recurrent hypoglycaemia, especially