EpsteinBarr Virus Start Here爱泼斯坦巴尔病毒从这里开始. Get There..pptVIP

Epstein-Barr Virus Terry Kotrla, MS, MT(ASCP)BB Diseases African or Burkitt’s Lymphoma malignant B-cell neoplasm presents as a rapidly growing tumour of the jaw, face or eye grows very quickly, and without treatment most children die within a few months Epstein-Barr virus (EBV) has been strongly implicated African or Burkitt’s Lymphoma Although BL is a very rapidly growing tumour it responds well to treatment. Three pictures: before treatment, 3 days and 6 days after treatment Nasopharyngeal Carcinoma Endemic in South China, Africa, Arctic Eskimos This is a malignant tumour of the squamous epithelium of the nasopharynx. 100% contain EBV DNA Rates are less than 1 per 100,000 in most populations Nasopharyngeal carcinomas are found in association with reactivation of latent Epstein-Barr Virus.? The exact mechanisms of association are unknown B-Cell Lymphoma In most individuals infected with EBV, the virus is present in the B-cells, which are normally controlled by T-lymphocytes When T-cell deficiency exists, one clone of EBV-infected B-lymphocytes escapes immune surveillance to become autonomously proliferating. EBV induced B cell lymphomas are most prevalent in immunocompromised patients. Oral Hairy Cell Leukoplakia Viral infection of the oral cavity. Indicator of HIV infection as well as of a persons lessening or weakening immunity Infectious Mononucleosis Downey cells may be present Heterophile Antigens/Antibodies An antigen or antigenic determinant which is found in different tissues in more than one species. These are antibodies found in one specie of animal (such as humans) which react against a component of another specie. Paul Bunnell Test The original Paul-Bunnell test was a simple titration of sheep cell agglutinins but this procedure was subsequently modified in order to distinguish between sheep cell agglutinins formed in IM and the Forssman-type antibodies found in normal serum, serum sickness and in certain other conditions. Tissues rich