疏肝理气清鼽汤治疗变应性鼻炎临床研究.docVIP

疏肝理气清鼽汤治疗变应性鼻炎临床研究 　　摘要：目的 评价疏肝理气清鼽汤治疗变应性鼻炎的临床疗效及安全性。方法 将74例变应性鼻炎患者按1∶1比例随机分为治疗组和对照组，治疗组采用自拟疏肝理气清鼽汤治疗，对照组予氯雷他定片口服治疗，7 d为1个疗程，连续治疗3个疗程。采用视觉模拟量表（VAS）评分、鼻眼结膜相关生活质量问卷调查量表（RQLQ）评分、血清特异性IgE（SIgE）检测值及总有效率对临床疗效进行评价，并统计不良反应。结果 所有患者均完成研究。治疗组总有效率为86.49%（32/37），对照组总有效率为89.19%（33/37），组间比较差异无统计学意义（P0.05）。2组VAS、RQLQ评分治疗前后比较差异均有统计学意义（P0.05），组间RQLQ评分比较差异有统计学意义（P0.05），对照组血清SIgE治疗前后比较差异有统计学意义（P0.05）。治疗组有2例患者出现轻微腹泻，余均无不良反应。结论 疏肝理气清鼽汤治疗变应性鼻炎具有良好的临床疗效及安全性。 　　关键词：变应性鼻炎；疏肝理气清鼽汤；随机对照试验 　　DOI：10.3969/j.issn.1005-5304.2016.07.010 　　中图分类号：R276.521.3 文献标识码：A 文章编号：1005-5304（2016）07-0038-04 　　Clinical Study on Shugan Liqi Qingqiu Decoction in the Treatment of Allergic Rhinitis JIAO Yu-juan， ZHANG Lian-yong， CUI Xue-liang （Jiaozhou Qingdao Center Hospital， Qingdao 266300， China） 　　Abstract： Objective To evaluate the clinical efficacy and safety of Shugan Liqi Qingqiu Decoction in the treatment of allergic rhinitis. Methods Totally 74 patients were randomly divided into treatment group and control group in a 1：1 ratio. The treatment group received the prescription of Shugan Liqi Qingqiu Decoction， and control group was given loratadine tablets orally， 7 days as a course of treatment and 3 courses successive. After treatment， the visual analogue scale （VAS）， Rhinocoujunctivitis Quality of Life Questionaire （RQLQ）， Specific IgE （SIgE） values and total effective rate were measured to evaluate the clinical efficacy， and the total number of cases of adverse reactions was statistically analyzed. Results After all the patients were researched， the total effective rate of treatment group was 86.49% （32/37） in the treatment group and 89.19% （33/37） in control group， without statistical difference （P0.05）. There was statistical difference in VAS and RQLQ between before and after treatment in the two groups （P0.05） in VAS and was statistical difference in RQLQ （P0.05） in SIgE in the treatment group， and was statistical difference （P0.05） in SIgE between the two groups after treatment. There was no a