硫酸镁联合小剂量阿司匹林治疗早发型子痫前期的效果.docVIP

硫酸镁联合小剂量阿司匹林治疗早发型子痫前期的效果 　　[摘要] 目的 探讨硫酸镁联合小剂量阿司匹林对早发型子痫前期患者母婴预后的影响。 方法 选取2013年10月～2015年10月苏州市立医院收治的100例早发型子痫前期患者，根据随机数字表法分为对照组和观察组。所有患者均接受传统硫酸镁解痉、降压治疗，对照组不给予阿司匹林抗凝，观察组持续口服肠溶阿司匹林片50 mg/d至分娩前。比较两组患者妊娠结局及围生儿结局。 结果 两组患者孕产次、平均年龄、孕龄及入院血压比较，差异无统计学意义（P 0.05）；观察组早产、肝肾功能损害、子痫、新生儿低体重、新生儿窒息发生率明显低于对照组，差异均有统计学意义（P 0.05）。 结论 小剂量阿司匹林能够改善子痫前期患者高凝状态，保护患者肝、肾功能，降低早产、子痫、新生儿窒息及低体重儿的发生率，而且不增加胎盘早剥、剖宫产和产后出血的发生率。 　　[关键词] 早发型子痫前期；小剂量阿司匹林；母婴预后 　　[中图分类号] R714.245 [文献标识码] A [文章编号] 1674-4721（2016）09（b）-0080-04 　　[Abstract] Objective To study the effect of magnesium sulfate combined with low-dose Aspirin on maternal and infant prognosis for early-onset preeclampsia. Methods One hundred patients with early-onset preeclampsia in Suzhou Municipal Hospital from October 2013 to October 2015， in accordance with the random number table， they were randomly assigned into observation group and control group. All the patients were treated with conventional magnesium sulfate and antihypertensive drug. Patients in observation group were given Aspirin orally at the daily dose of 50 mg before delivery， while patients in control group were not given anticoagulant drugs. Pregnancy and perinatal outcome in the two groups were compared. Results Times of gestation and parity， average age， gestational week and blood pressure on admission between the two groups had no significant difference （P 0.05）. The incidence of premature delivery， liver and kidney function damage， eclampsia， low birth weight and neonatal asphyxia in the observation group were significantly lower than those in the control group （P 0.05）. Conclusion Low-dose Aspirin can improve the high coagulation state of patients with preecl-ampsia， protect liver and kidney function， reduce the incidence of eclampsia， premature delivery， neonatal asphyxia and low birth weight infants， and does not increase the incidence of placental abruption， caesarean section and postpartum hemorrhage. 　　[Key words] Early-onset preeclampsia； Low-dose Aspirin； Prog