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Screening outcomes of household contacts of multidrug-resistant tuberculosis patients in Peshawar, Pakistan.pdf

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Screening outcomes of household contacts of multidrug-resistant tuberculosis patients in Peshawar, Pakistan.pdf

Asian Paci?c Journal of Tropical Medicine 2016; 9(9): 909–912 909 HOSTED BY Contents lists available at ScienceDirect Asian Paci?c Journal of Tropical Medicine journal homepage: /apjtm Original Research /10.1016/j.apjtm.2016.07.017 Screening outcomes of household contacts of multidrug-resistant tuberculosis patients in Peshawar, Pakistan Arshad Javaid1,2, Mazhar Ali Khan2*, Mir Azam Khan3, Sumaira Mehreen2, Anila Basit1,2, Raza Ali Khan4, Muhammad Ihtesham2, Irfan Ullah2, Afsar Khan2, Ubaid Ullah2 1Post Graduate Medical Institute, Lady Reading Hospital, Peshawar, Pakistan 2Programmatic Management of Drug Resistant TB Unit, Lady Reading Hospital, Peshawar, Pakistan 3Peshawar Medical College, Peshawar, Pakistan 4Kohat University of Science and Technology, Kohat, Pakistan ARTICLE INFO Article history: Received 17 May 2016 Received in revised form 16 Jun 2016 Accepted 1 Jul 2016 Available online 26 Jul 2016 Keywords: Tuberculosis Household contacts MDR-TB Peshawar Pakistan ABSTRACT Objective: To assess the pro?le of TB/multidrug-resistant TB (MDR-TB) among household contacts of MDR-TB patients. Methods: Close contacts of MDR-TB patients were traced in the cross-sectional study. Different clinical, radiological and bacteriological were performed to rule out the evidence of TB/MDR-TB. Results: Between January 2012 and December 2012, a total of 200 index MDR-TB patients were initiated on MDR-TB treatment, out of which home visit and contacts screening were conducted for 154 index cases. Of 610 contacts who could be studied, 41 (17.4%) were diagnosed with MDR-TB and 10 (4.2%) had TB. The most common symptoms observed were cough, chest pain and fever. Conclusions: The high incidence of MDR-TB among close contacts emphasize the need for effective contact screening programme of index MDR-TB cases in order to cut the chain of transmission of this disease. 1. Introduction Multidrug-resistant tuberculosis (MDR-TB) is caused by strain of Mycobacterium tuberculosis that is resistan