Therapeutic outcomes of combined topical autologous serum eye drops with silicone–hydrogel soft contact lenses in the treatment of corneal persistent epithelial defects A preliminary study.pdfVIP
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Therapeutic outcomes of combined topical autologous serum eye drops with silicone–hydrogel soft contact lenses in the treatment of corneal persistent epithelial defects A preliminary study.pdf
Contact Lens and Anterior Eye 39 (2016) 425–430
Contents lists available at ScienceDirect
Contact Lens and Anterior Eye
journal homepage: /locate/clae
Therapeutic outcomes of combined topical autologous serum eye drops with silicone–hydrogel soft contact lenses in the treatment of corneal persistent epithelial defects: A preliminary study
Yu-Kuei Leea, Yen-Chun Lina, Shih-Hao Tsaia, Wei-Li Chenb, Yan-Ming Chena,b,*
a Department of Ophthalmology, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan b Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan
ARTICLE INFO
Article history: Received 2 April 2016 Received in revised form 8 June 2016 Accepted 10 June 2016
Keywords: Corneal epithelial defects Autologous serum eye drops Silicone–hydrogel contact lens Persistent epithelial defects Bandage contact lenses
ABSTRACT
Purpose: To evaluate the ef?cacy of the combination of topical 20% autologous serum eye drops (ASEs) and silicone–hydrogel soft contact lenses (SCLs) for the treatment of corneal persistent epithelial defects (PEDs), and to compare the recurrence of epithelial breakdown with or without continuous use of ASEs after silicone–hydrogel SCLs removal. Methods: We conducted a prospective interventional study of 21 eyes of 21 patients with PEDs treated with combined ASEs and silicone–hydrogel SCLs from September 2014 to August 2015. SCLs were removed after total re-epithelialization and patients were subsequently randomized divided into two groups: (1) with and (2) without continuous use of ASEs for an additional 2 weeks. PEDs healing rate and epithelial defect recurrence were evaluated. Results: PEDs healed in all eyes within 3 weeks. Recurrence was noted in ?ve eyes (50%) in patients without continued use of ASEs for 2 weeks after total re-epithelialization and SCLs removal during a 3month follow-up (odds ratio: 23.0; P 0.05). Recurrent epithelial defects were successfully treated with secondary SCLs application combined with autologo
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