赣南地区糖化血红蛋白与2型糖尿病患者慢性并发症的相关性研究.docVIP

赣南地区糖化血红蛋白与2型糖尿病患者慢性并发症的相关性研究 　　摘要：目的 调研赣南地区2型糖尿病患者（T2DM）糖化血红蛋白（HbA1c）的水平与其慢性并发症的关系。方法 选取我院2014年1月～2016年1月内分泌科就诊的500例2型糖尿病患者，根据HbA1c水平分为三个组：A组≤7.0%、B组7%HbA1c 10%和C组≥10%，测定空腹血糖、其他生化指标及糖尿病相关并发症的筛查。结果 三组间患者的血压、TC和HDL-C无显著性差异（P0.05）。FBG、TG、和LDL-C水平比较差异显著性差异（P0.05），与HbA1c呈正相关；随着HbA1c水平上升，糖尿病视网膜病变（DR）、糖尿病肾病和冠心病、脂肪肝的发病率升高（P0.05）。糖尿病周围神经病变、糖尿病足（DF）和脑梗死的发病率组间差异无统计学意义。结论 糖尿病患者的慢性并发症的发生随着HbA1c的升高而增加，积极严格控制2型糖尿病患者的HbA1c有利于防治糖尿病并发症的发生于发展。 　　关键词：糖化血红蛋白；2型糖尿病；慢性并发症 　　The Correlation Study of Glycosylated Hemoglobin and Chronic Complications in Type 2 Diabetes of Gannan Area 　　ZHONG Shu-mei，YIN Ying，ZHANG Si-qing，ZENG Xian-zhong，XI Yan-hua，LI Xiao-yan 　　（Department of Endocrinology and Metabolism， Ganzhou Peoples Hospital， Ganzhou 341000， Jiangxi， China） 　　Abstract：Objective To study the correlation of glycosylated hemoglobin and chronic complicationsin type 2 diabetes of Gannanarea. Methods 500 cases of type2 diabetes patients in our department of Endocrinology from Janurary2014 to Janurary2016. According to the HbA1c they were divided intoA group≤7.0%， B group 7%HbA1c 10% and Cgroup≥10%，FBG，biochemical indicators weremeasured and diabetic complications were screened in all subjects.Results There was no significant difference in blood pressure，TC and HDL-C among three groups（P0.05）.There were statistically significant differences inFBG， TGandLDL-C （P0.05）， andpositively correlatedwith the HbA1c.The incidence of diabetic retinopathy（DR）， coronary heart disease （CHD） ，diabetic nephropathy（DN）and fatty liver increased markedly along with the elevation of HbA1c levels（P0.05）. There was no significant difference intheincidence of diabetic peripheral neuropathy（DNP）， cerebral infarction and diabetic foot. Conclusion Chronic complications in diabetic patientsclosely related to glycosylated hemoglobin content， andwith elevated HbA1c increase， strict control of type 2 diabetes HbA1c in favor of prevention and treatment of diabetic complications occur in development. 　　Key words