前列腺组织双氢睾酮结合容量与年龄的关系及意义.pdfVIP

:12 Chinese Journal of Andrology Vol. 21 No. 1 2007 前列腺组织双氢靠自问结合容量与年龄的关系及意义 暨南大学Ifl学院附J在深圳市人氏庭院必乐外科(深圳 518020) ?工 1共济 陈 ag 典浏江大学医学院附属;在… l盖自t，;击乐外科 摘要 目的 研究前列腺组织观纸旦在四日 (DHT) 结合容;在与年龄变化的关系和在前列腺增尘病囱中的作 JIJ 为活 22 例前列腺熠生划生}\、 11 例网坏龄段Xt ft试前列腺组织、 20 j甘l 州对坏份的lEìi\前列腺组织，川;~备§且 rr、 肺A蝶、IlIM:生摄取液，以旧 -DHT测定结合容最ε 结果前列腺熠生组l和同年龄段对照细腑浆Z13乱骂骂酬结合容最甘圳 J; (0.0128土 0.0020) nmol/g ii盖纠织、 (0.0125主0.0018) nmollg 溢2日织，差异?巳统计学怒义 (P 0.05) ，但约 内 f拟对年1茫的 11:.常锐的 (0.0103;;0.0015 )时nol/g 1邸拟织，亲在始有统计学瑜、义 (PO.()1)。纺论 自自ij:龄 增K:前列腺组织、血浆的双氧擎翻结合能力显著增加，有利 T提高艰氯兰在闸食最井影响前;9IJ 艘巨11织熠生 关键i司 削 JIJ隙; 前列腺增生; 雄擞数炎， 蹄做皇量约1告说白J1Jí 中图分拨号 Q 579.1.1; R 339. 3 丁he relationship between Dihydrotestosterone -binding capacity of prostate and age Jiang Hongtao Departm.α时 of Urolog苦， the Shenzhen Peoples Hospital Affiliated 10 Medical College, Jinan UniversilY, Shenzhen 518020. China Chen Zhaodían D呼目阳酬ofUrolo.霄， thcji，时 lfospi.拥!lAifiliated 10 Med，时!l College, Zh时iang U，盹versí;η Abstract Objectives To study the relatìonship between the DHT binding capacity of prostate and changíng age and to s!udy the errect of capacity on the prostatic hyperplasi. 如fethods To obtain cytosolk and nuclcar fractions from 22 Bcnign prostatic hyperplasia (?PH) tissues, J 1 prostate tíssues of the same age for contrnl , and 22 normal ti5sues, and then the content of the bound J日 DHT was assayed. Results The DHT-bìnding capaC?ties of the cytosolic fractions in prootate in BPH group and control group are (0.0128ω 创l20)runoVg wet tissue and (0.0125~O.OO18)nmoVg W时 U冉归队副ffiβ阳~ncc of由e two capacitics bcing not significant (PO.05). The capaciti剧。If the BPH group and coulro] group are bo也 higher th扭曲.at of the nonn创 group (PO.Ol) , the latter bcing (0.0103士。∞15)nmol/g wet tissue. Conclusion The DHT~bindìng capacity of the cytosolìc fract?on s. in prostate signit?cantly ìncreases with aging and promotes the DHT contcnt and fac i1itatcs thc effect of the DHT on BPH Key words prostate; prostatic hyperplasia; androgens; androgen占in