Acupuncture paclitaxel on lung cancer in rats tropism of liposomes.docVIP

 PAGE \* MERGEFORMAT 12 Acupuncture paclitaxel on lung cancer in rats tropism of liposomes Of: Cheng Ze Dong, Wang Zhenguo, Chen States [Abstract] Objective To observe acupuncture “Feishu”, “too deep” on the paclitaxel liposome in rats trends of lung cancer effects of anticancer drugs targeted to open new avenues for research. Methods paclitaxel liposome labeled with 99m Tc, the choice of a simple intravenous injection of drugs and drug injection, respectively, with acupuncture, “Feishu”, “Taiyuan” (related points), “gate of God” (unrelated points) combining 4 successful modeling methods intervention of lung cancer in rats (n = 18). respectively after intravenous injection 60,90,120 min (6 rats per time point) rats were killed after immunization with γ-radiation counter lung were measured, liver, kidney and other organs of paclitaxel liposome drug content. Results of acupuncture, “Feishu” and “too deep” in all or part of the time points in lung tissue from lung cancer was increased paclitaxel liposome. acupuncture “Shenmen “failed to higher drug content in lung tissue. Conclusion Acupuncture” Feishu “and” too deep “on the paclitaxel liposome in the distribution of lung cancer in rats tend to influence,” Feishu “target drug in the lung directional impact than “too deep.” [Keywords:] acupuncture, paclitaxel liposome, lung, rat Abstract: Objective To observe the effect on body distribution tendency of paclitaxel liposome in the lung cancer rats after acupuncture of Feishu, Taiyuan acupoints in order to develop the new path for the target study of anticancer drugs. Method The paclitaxel liposome was labeled by technetium ( Tc). Four methods including tail intravenous injection of paclitaxel liposome merely and the combination of tail intravenous injection of paclitaxel liposome with acupuncture of Feishu, Taiyuan (concerned acupoint) and Shenmen (unconcerned acupoint) acupoints respectively were carried on the intervention to the lung cancer rat models