Advances in animal models of liver cirrhosis.docVIP

 PAGE \* MERGEFORMAT 16 Advances in animal models of liver cirrhosis Study: New Chen, Pan Hua, Zheng Yuemei, XIONG [Keywords:] animal models of liver cirrhosis; anesthetics; liver Most of anesthetic metabolism in the liver, liver cirrhosis and post-operative wake of anesthetics influenced the establishment of a similar animal model of human liver cirrhosis and cirrhosis of the liver-depth study of an essential part of the subject. Ideal cirrhosis model should with the basic form of human liver cirrhosis, and their pathological stage was the progress, and the modeling method is simple, the model formation rate, reproducible, low mortality rate. cirrhosis of the liver because of the diversity of causes, animals and human species differences, so far Li Xiang Gan Yinghua animal model of clinical research and is still a difficult experimental studies, the ideal model-making has not been fully successful. viral cirrhosis models, particularly human hepatitis B virus infection in animals model, should be the ideal animal model of liver cirrhosis. However, people infected with hepatitis B virus and only a small number of primates, so a long time, the lack of actual available animal models, chemical and composites are prepared by factors such as the liver hardening model more common. domestic and foreign scholars have done a lot of animal experiments, some of the more mature established animal model of liver cirrhosis. As different pathogenic factors of each model, resulting in cirrhosis of the specific mechanisms, stability, repeatability, and with process similar to the degree of human disease are also different. In this paper, recent progress in animal model of liver cirrhosis are reviewed. 1 to CCl4-induced cirrhosis model-based Cameron 1936 [1] first reported the production of cirrhosis of the liver CCl4 animal model, then, CCl4 widely used in animal experiments. CCl4 is a chemical poison, which acts on the liver caused by repeated acute or chronic li