Corneal alkali burn and the research progress of Lymphangiogenesis.docVIP

 PAGE \* MERGEFORMAT 16 Corneal alkali burn and the research progress of Lymphangiogenesis [Keywords:] corneal alkali burn Clinically, corneal alkali burn is complex and difficult to cure eye disease, one of alkaline substances dissolve in water and soluble in both fat, and thus into the cells, can rapidly and cell structure of the lipids saponification reaction, the formation of compounds with a two-phase solubility, both quickly penetrate the lipophilic nature of the conjunctiva, corneal epithelium and endothelium, but also penetrate the cornea with a hydrophilic matrix and scleral tissue, it is easily penetrate the eye tissue of deep, damage the eye tissue. 1 in the pathogenesis of corneal alkali burn and treatment 1.1 The pathogenesis of corneal alkali burn He Jiu-1.1.1 into neutrophils [1] found that corneal ulcer area is characterized by significant leukocyte infiltration into the injured area leukocytes significantly faster than the epithelial cells of synthetic cell, a large number of severe leukocyte infiltration after alkali burn matrix, which is addressed the main reason for aseptic ulceration and perforation. IL-1, TNF-1 @ such as alkali burns in major inflammatory mediators, can mediate neutrophil aggregation [2]. 1.1.2 collagenase matrix metalloproteinase (matrilinearmetalprotease, MMP) is able to degrade the extracellular matrix of zinc protease, a large number of MMP role in corneal epithelial and stromal collagen, can cause collagen solution, the formation of corneal ulcers, and even perforation [3]. 1.1.3 The destruction of anterior chamber-associated immune deviation is characterized by selective inhibition of antigen-specific. Corneal alkali burns, the blood - aqueous barrier open, iris and ciliary damage, a variety of factors secreted by the ciliary body was different levels of interference or disappear. anterior chamber-associated immune deviation mechanism of this protection has been destroyed, contributing to the cor