Danshen injection on chronic obstructive pulmonary disease model rat transforming growth factor β1 in_0.docVIP

 PAGE \* MERGEFORMAT 11 Danshen injection on chronic obstructive pulmonary disease model rat transforming growth factor β1 in [Abstract] Objective To study the Salvia injection on chronic obstructive pulmonary disease (COPD) airway remodeling in rats and its mechanisms of intervention. Methods of cigarettes smoked tracheal endotoxin methods COPD rat model. At the same time the establishment of model group, SM group and control group, HE staining of lung tissue with pathological changes and collagen deposition, measured by ELISA test kit in serum and lung tissue transforming growth factor β1 (TGF-β1) level, by immunohistochemical staining and TGF-β1 in lung tissue. The results of serum TGF-β1 content in the control group the highest, followed by SM group, model group was the lowest, 3, no significant difference between groups (P allgt; 0.05 ), lung tissue levels of total TGF-β1 than the control group and model group, SM group, the difference was statistically significant (P lt;0.05), SM group was higher than the control group, but the difference was not statistically significant (Pgt; 0.05 ), lung tissue TGF-β1 mRNA expression in model group, the strongest, and the control group, SM group was significantly (P lt;0.05), SM group compared with the control group no significant difference (Pgt; 0.05). Conclusion TGF-β1 in the airway remodeling in COPD pathogenesis, Danshen injection can interfere with TGF-β1 decreased airway remodeling in COPD. [Keywords:] injection, chronic obstructive pulmonary disease, airway remodeling, transforming growth factor β1, rat Keywords:: Dansheng injection, COPD, airway remodeling, transforming growth factor-β1, rat With the aging of the population, the increase in smokers and increased environmental pollution, chronic obstructive pulmonary disease (Chronic obstructive pulmonary disease, COPD) prevalence has increased year after year, the main world economic burden of disease. Therefore, COPD prevention and treatment bec