Danshen sustained-release tablets of borneol inclusion technology.docVIP

 PAGE \* MERGEFORMAT 12 Danshen sustained-release tablets of borneol inclusion technology Study: New Li Yuan, Cai Xuling, Huo Services Zhen, Shan Sheng Zhu [Abstract] Objective Danshen sustained-release tablets to enhance the stability of borneol to improve its in vitro release of borneol of cyclodextrin inclusion research. Methods saturated aqueous solution method, and orthogonal GC to the ratio of borneol and cyclodextrin, inclusion time, standing time and drying method factors to the inclusion rate of borneol, the yield index inclusion, inclusion process optimization of technical parameters borneol investigated before and after inclusion of borneol in vitro release. Results The optimum parameters: borneol and cyclodextrin weight ratio of 1:6, the inclusion time was 0.5 h, holding time 1.5 h, pressure 50 drying; of ice obtained by the inclusion rate was 96.16%, inclusion yield was 98.95%. Conclusions The inclusion process is simple, easy to operate, and the inclusion rate and the inclusion yield, for Development of Danshen tablets. [Keywords:] borneol; cyclodextrin; orthogonal test; process parameters; in vitro release Abstract: Objective To enhance the stability of borneol in compound danshen sustained release tablets and improve their in vitro release with the clathration technology of borneol with cyclodextrin. Methods Saturation water solution, GC MS and orthogonal experiment with the ratio between bemeol and cyclodextrin, clathration time, standing time and drying method as technology parameters were applied. In vitro release of borneol, the clathration rate and yield were observed. Results The optimized clathration technology parameters were as follows: the ratio between Bemeol and cyclodextrin was 1: 6 ( g: g), inclusion time was 0.5 h, standing time was 1.5 h and dried at 50 NP. The borneol clathration ratio was 96.16%, and the clathration yield was 98.95%. Conclusion The clathration technology parameters of borneol are reasonable