Different iodine intake on iodine metabolism and thyroid function in rats affect.docVIP

 PAGE \* MERGEFORMAT 4 Different iodine intake on iodine metabolism and thyroid function in rats affect Authors: Yan Ye, Wang Kun, Zhang Lu, Lin Lai-xiang, Liu Jiayu, YAN Yuqin,陈祖培 [Abstract] Objective To observe the potassium iodate (KIO3) rat model of intake of iodine metabolism and thyroid function changes and to explore KIO3 security. Methods Wistar rats were randomly divided into six groups, were given a low iodine, iodine, and iodine (iodine groups, respectively 5,10,50,100 times) diet, test 3,6 and 12 months the level of urinary iodine and thyroid iodine content, analysis of iodine metabolism; 3 were detected by serum total iodine A gland acid (TT3), total thyroxine (TT4), free triiodo-A gland acid (FT3), free thyroxine (FT4) concentrations and thyroid gland tissue triiodo-A acid (T3), thyroxine (T4) levels to measure thyroid function. LI Results of urinary iodine level and thyroid iodine content, as well as serum thyroid hormone in thyroid tissue was significantly lower than the iodine group, was significantly lower thyroid function; the HI urinary iodine excretion increased significantly increase the rate of iodine multiples of intake consistent with, but compared with the iodine, the thyroid iodine content in the HI group the maximum is only two times; In addition, HI group with an increase in iodine intake, serum and thyroid tissue in thyroid hormone levels appears to reduce the trend, showing a certain degree of hypothyroidism. Conclusions Long-term iodine deficiency and iodine excess can lead to low thyroid function in rats, but hypothyroidism caused by iodine deficiency more apparent. At the same time a mechanism in rats can adapt to high iodine on the iodine intake has a greater tolerance, and confirmed that KIO3 security. [Keywords:] Iodine; iodine metabolism; thyroid hormone; potassium iodate Iodine is the body’s essential trace elements, is the synthesis of thyroid hormone thyroid basic raw materials. The body in insufficient or excessiv