Dopamine D1 receptors in Parkinson brain substantia nigra of the expression.docVIP

 PAGE \* MERGEFORMAT 10 Dopamine D1 receptors in Parkinson brain substantia nigra of the expression Study: Fan Weiwei Guo Ping Wang Lei Shi Ge Kang Yunxiao [Abstract] Objective To observe the Parkinson’s (PD patients brain nigrostriatal dopaminergic D1 receptor expression. Methods immune autoradiographic specimens were observed by PD (PD group) in the nigrostriatal dopaminergic D1 receptor content change, and with the brain specimens of non-neurological diseases (control group) were compared. Results of dopamine D1 receptors labeled PD group signal in the caudate nucleus shell and weaker than the control group, substantia nigra dopamine D1 receptor signaling than the control group tags enhanced gray value analysis, shell and caudate nucleus of the gray value than the control group increased by 11.35% and 10.52%, while the substantia nigra than in the control group reduced 48.89% (P lt;0.01. Conclusion dopamine D1 receptors in Shell and PD human brain specimens decreased expression of the caudate nucleus, substantia nigra expression. [Keywords:] Parkinson’s disease, dopamine D1 receptor, striatum, substantia nigra Studies have shown that Parkinson’s disease (Parkinson’s disease, PD is the Central nigra dopaminergic neuron degeneration caused a decrease in the striatum corresponding nerve neurodegenerative diseases, the current levodopa (L DOPA replacement therapy is still the main treatment for PD (1), the early stages of the disease will play a very good treatment, but efficacy appears disorders such transactions decreased and the treatment of side effects of the PD (2). L DOPA side effects of the mechanism is not very clear, suggesting that changes in dopamine receptor expression, leading to basal ganglia disorders efferent activity. studies show that dopamine D1 receptors are distributed in the basal ganglia efferent pathways direct pathway GABA medium spiny neurons there (3), in the movement plays an important role in regulation (4), the expressi