Dopamine magnesium sulfate treatment of neonatal hypoxic ischemic encephalopathy of.docVIP

 PAGE \* MERGEFORMAT 12 Dopamine magnesium sulfate treatment of neonatal hypoxic ischemic encephalopathy of Of: Yang Lijuan, Yang Xiaochun, Yuan Yufang [Abstract] Objective To investigate dopamine magnesium sulfate on neonatal hypoxic-ischemic encephalopathy (HIE) of the brain in rats. Methods 60 patients were randomly divided into dopamine magnesium sulfate group (D), one with magnesium sulfate group ( L), saline group (C) three groups, while the normal control group (N), measured in each group were admitted to hospital after admission and 48 h, 72 h and 7 days each time point of serum S100 protein, creatine kinase brain type isoenzyme (CK-BB), and in the treatment of patients during the monitoring respiration, heart rate and blood pressure. outcome group and L group D patients hospitalized 48 h, 72 h and 7 days of blood S100 protein, CK-BB concentration increased significantly less than the C group (P lt;0.01, P lt;0.05), D group of children with respiratory depression, heart rate and blood pressure were significantly lower than the L group. Conclusions of dopamine on magnesium sulfate had cerebral protective effect in children with HIE, while reducing the adverse effects of magnesium sulfate alone. [Keywords:] magnesium sulfate; dopamine; neonatal hypoxic ischemic encephalopathy Abstract: Objective To investigate the protective effect of magnesium sulfate combined with dopamine on the brain of neonates with hypoxic-ischemic encephalopathy (HIE). Methods 60 neonates with HIE were randomly divided into magnesium sulfate with dopamine group (D), magnesium sulfate alone group (L) and normal saline group (C) to contrast with the normal control group (N). Serum levels of creatine phosphokinase isoenzyme BB (CK-BB) and S-100 protein were observed in the 4 groups at different time points (admission and 48 h, 72 h and 7 days of hospitalization). The variations in respiration rate, heart rate and blood pressure were monitored during the treatment.Results C