Drugs in vivo and in vitro evaluation methods and the relationship between.docVIP

 PAGE \* MERGEFORMAT 32 Drugs in vivo and in vitro evaluation methods and the relationship between Paper Keywords: biopharmaceutics classification system for dissolution of the bioavailability bioequivalence vivo and in vitro correlation Abstract: Objective: Overview of drug in vivo - in vitro evaluation methods and their interrelationship; Methods: Review of the literature at home and abroad; Results: Summary of domestic and international basic research method of dissolution and bioavailability of the evaluation method we can see that to study a a pharmaceutical preparation in vivo - in vitro correlation aims to create a description of the in vitro bioavailability of quality standards, and used as indicators of quality control during mass production preparation; Conclusion: For a good in vivo - in vitro correlation of drug, By measuring the in vitro drug dissolution can be predicted in vivo bioavailability. KEY WORDS: Biopharmaceutical classification system; dissolution; bioavailability; bioequivalence; in vivo-in vitro relationship ABSTRACT OBJECTIVE: To summarize the research and evaluation methods between in vivo and in vitro of drugs and their relationships; METHODS: To analyze the domestic and overseas relative literatures; RESULTS: Known by summarizing the basic research and evaluation methods of dissolution and bioavailability / bioequivalence , the aim of researching the IVIVC is to set up the in-vitro quality standard which can illustrate the bioavailability and the QC index between batch and batch in production; CONCLUSION: The dissolution results of drugs can predict it’s bioavailability if the relationship between in - vivo data and in-vitro metric is fine. 1, Introduction Is well known that oral or topical formulations, the absorption of its active ingredients is affected by many factors, in which internal factors, the factors known to affect absorption of the preparation process, drug particle size, crystal type or multi-crystalline for