Dragons Blood Preparation of solid dispersion and dissolution study of effects.docVIP

 PAGE \* MERGEFORMAT 10 Dragon’s Blood Preparation of solid dispersion and dissolution study of effects [Abstract] Objective To determine the Dragon’s Blood from solid dispersions prepared by the best way. Preparation of solid dispersion method of study methods, different carriers and carrier Dragon’s Blood Dragon’s Blood on the different proportions between the dissolution characteristics. Dragon’s Blood from the results of the dissolution of solid dispersion was significantly higher than effects of Dragon’s Blood and the carrier physical mixture. Conclusion Dragon’s Blood with poloxamer 188 by 1:4 (mass ratio), the ratio, using solvent - Dragon’s Blood melt prepared solid dispersions dissolution effect increases dramatically. [Keywords:] Dragon’s Blood; solid dispersion; dissolution effect Abstract: Objective To optimize the method of preparing Dragon’s blood solid dispersion. Method Compare different results of various preparations, carriers, and the ratio between the carriers and Dragon’s blood.Result Tests show that Dragon’s blood solid dispersion dissolute more than its physical mixtures. Conclusion The solid dispersion of Dragon’s blood  Pluronic F68 with the proportion of 1 to 4 prepared by solvent evaporation  fusion method accelerates its dissolution remarkably. Keywords:: Dragon’s blood; solid dispersion; dissolution Dragon’s Blood (Dragon’s blood) is the a traditional Chinese medicine for promoting blood circulation of flavonoids in the main active ingredient [1]. Dragon’s Blood flavonoids on experimental venous thrombosis significantly inhibited [1], can significantly reduce the coronary artery ligation-induced acute myocardial ischemia-induced myocardial infarct size and reduce the myocardial ischemia-induced Ⅱ ECG limb elevated J-point [2]. Dragon’s Blood flavonoids difficult to dissolve in water, soluble in 95% ethanol [3], to improve its dissolution in water, the experiment using solid dispersion technology, from the supplementary ma